Design and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues

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dc.contributor.authorValderrama, Jaime A.
dc.contributor.authorVasquez, David
dc.date.accessioned2024-01-10T13:47:27Z
dc.date.available2024-01-10T13:47:27Z
dc.date.issued2008
dc.description.abstractThe preparation of two pyrimido[4,5-c]isoquinoline-7, 10-quinones from acylhydroquinones and 1,3-dimethyl-5-aminouracil and their cycloadditions with 1-trimethylsilyloxybutadiene and 1-dimethylamino-3-methyl-1-azabutadiene is described. The remarkable regio-control of these cycloadditions that yield stable 1:1 cycloadducts is discussed on the basis of steric interactions into the pyrimido[4,5-c]isoquinoline-7,10-quinones. The access to angucyclinone AB-pyridopyrimidine analogues from Diels-Alder adducts and preliminar evidences on their antitumour activities are also reported. (c) 2007 Elsevier Ltd. All rights reserved.
dc.fechaingreso.objetodigital11-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.tetlet.2007.11.133
dc.identifier.issn0040-4039
dc.identifier.urihttps://doi.org/10.1016/j.tetlet.2007.11.133
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79271
dc.identifier.wosidWOS:000253279200030
dc.information.autorucQuímica;Valderrama J;S/I;98772
dc.information.autorucQuímica;Vásquez D;S/I;117510
dc.issue.numero4
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final706
dc.pagina.inicio703
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.revistaTETRAHEDRON LETTERS
dc.rightsacceso restringido
dc.subjectquinones
dc.subjectMichael addition
dc.subjectdiels-alder reaction
dc.subjectregioselectivity
dc.subjectIN-VITRO
dc.subjectCYTOTOXICITY
dc.subjectAPOPTOSIS
dc.subjectPHOTOCHEMISTRY
dc.subjectANTIBIOTICS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDesign and synthesis of angucyclinone AB-pyrido[2,3-d] pyrimidine analogues
dc.typeartículo
dc.volumen49
sipa.codpersvinculados98772
sipa.codpersvinculados117510
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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