Hepatic fatty acid profile in mice with nonalcoholic fatty liver disease using magnetic resonance spectroscopy

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dc.catalogadorpva
dc.contributor.authorXavier, Aline Carvalho da Silva
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorCabrera García, Daniel Alejandro
dc.contributor.authorFuenzalida, Karen
dc.contributor.authorAndía Kohnenkampf, Marcelo Edgardo
dc.date.accessioned2023-08-24T20:15:01Z
dc.date.available2023-08-24T20:15:01Z
dc.date.issued2019
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of intracellular fatty acids in the liver. The only method to confirm the stage of this disease is the biopsy, but it is invasive and risky to patients. The idea of defining a classifier using magnetic resonance spectroscopy (MRS) emerges due to the need to find a way to replace biopsy with a non-invasive method that can classify NAFLD based on the chemical structure of fatty acids stored in the liver. The purpose of this study is to investigate and compare the composition of fatty acids to the metabolites signals in MRS in NAFLD mice liver at 2 time-point during the progression of the disease. A group of C57BL/6 mice was fed with high-fat diet for one month (N = 8) and for three months (N = 6). First, we made a histological analysis to the liver. Then, we analysed the fatty acids with gas chromatography (GC) and MRS. As a result, the histological analysis showed the progression of fat content, and the GC analysis detected a different fatty acid liver composition during the progression of NAFLD along with an increase of the total fat storage in the liver. The differences in the composition fatty acids are also reflected in the MR Spectrum, which could have clinical potential for monitoring the progression of this disease with a non-invasive technique.
dc.description.funderVRAID (ex DIPUC)
dc.fechaingreso.objetodigital2023-08-24
dc.fuente.origenHistorial Académico
dc.identifier.citationCarvalho Da Silva Xavier Aline, Zacconi Flavia Cristina Milag, Cabrera Garcia Daniel Alejandr, Andia Kohnenkampf Marcelo Edga. Hepatic fatty acid profile in mice with nonalcoholic fatty liver disease using magnetic resonance spectroscopy. 2019;(1):51-56.
dc.identifier.doi10.1007/978-981-13-2119-1_8
dc.identifier.isbn978-981-13-2118-4
dc.identifier.issn1680-0737
dc.identifier.urihttps://doi.org/10.1007/978-981-13-2119-1_8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74488
dc.identifier.wosidWOS:000503191900008
dc.information.autorucEscuela de Ingeniería; Xavier, Aline Carvalho da Silva; 0000-0001-6793-341X; 1030565
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.information.autorucEscuela de Medicina; Cabrera García, Daniel Alejandro; 0000-0002-9055-4191; 126029
dc.information.autorucEscuela de Ingeniería; Andía Kohnenkampf, Marcelo Edgardo; 0000-0002-1251-5832; 90691
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final56
dc.pagina.inicio51
dc.relation.ispartofXXVI Brazilian Congress on Biomedical Engineering (pp. 51–56).
dc.revistaIFMBE proceedingses_ES
dc.rightsacceso restringido
dc.subjectMagnetic resonance spectroscopyes_ES
dc.subjectNAFLDes_ES
dc.subjectFatty acidses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHepatic fatty acid profile in mice with nonalcoholic fatty liver disease using magnetic resonance spectroscopy
dc.typecomunicación de congreso
dc.volumen70/1
sipa.codpersvinculados1030565
sipa.codpersvinculados1011127
sipa.codpersvinculados126029
sipa.codpersvinculados90691
sipa.indexWoS
sipa.indexScopus
sipa.trazabilidadHistorial Académico;09-07-2021
sipa.trazabilidadORCID;2023-08-21
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