Spirometry reference values after inhalation of 200 mu g of Salbutamol

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dc.contributor.authorPerez Padilla, Rogelio
dc.contributor.authorTorre Bouscoulet, Luis
dc.contributor.authorCarlos Vazquez Garcia, Juan
dc.contributor.authorMuino, Adriana
dc.contributor.authorMarquez, Maria
dc.contributor.authorVictorina Lopez, Maria
dc.contributor.authorde Oca, Maria Montes
dc.contributor.authorTalamo, Carlos
dc.contributor.authorValdivia, Gonzalo
dc.contributor.authorPertuze, Julio
dc.contributor.authorJardim, Jose
dc.contributor.authorMenezes, Ana Maria B.
dc.contributor.authorGrp PLATINO
dc.date.accessioned2024-01-10T13:10:05Z
dc.date.available2024-01-10T13:10:05Z
dc.date.issued2007
dc.description.abstractOBJECTIVE: The criteria for disease severity established by the Global Initiative for Chronic Obstructive Lung Disease are based on forced expiratory volume in I second (FEV) expressed as a percentage of the predicted value after application of a bronchodilator. This study aims to determine postbronchodilator spirometry reference values.
dc.description.abstractSUBJECTS AND METHODS: A cluster sample of subjects aged 40 years or over was chosen to be representative of the metropolitan areas of 5 Latin American cities (Sao Paulo, Mexico City, Montevideo, Santiago, and Caracas). Spirometry was performed on 5183 subjects following the recommendations of the American Thoracic Society before and after inhalation of 200 mu g of salbutamol. Multiple linear regression equations were fitted for the postbronchodilator spirometric values-FEV1, forced expiratory volume in 6 seconds (FEV6), peak expiratory flow rate, forced vital capacity (FVC), FEV1/FEV6, FEV1/FVC and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75). These were adjusted for sex, age, and height in 887 asymptomatic subjects with no history of lung disease.
dc.description.abstractRESULTS: The postbronchodilator reference values for FEV, FEV1/FVC, and FEV1/FEV6 were on average 3% higher than those obtained before bronchodilation. This apparently small difference caused an upward shift in the 5th percentile (lower limit of normal) of the predicted values. When prebronchodilation instead of postbronchodilation reference values were used, 3.2% of the results for airflow obstruction in our population of over-40-year-olds were false negatives.
dc.description.abstractCONCLUSIONS: The reported reference values are more appropriate for postbronchodilator spirometry and make it possible to reduce the number of misclassifications.
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1157/13110877
dc.identifier.eissn1579-2129
dc.identifier.issn0300-2896
dc.identifier.pubmedidMEDLINE:17939906
dc.identifier.urihttps://doi.org/10.1157/13110877
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77763
dc.identifier.wosidWOS:000250411000002
dc.information.autorucFacultad de Medicina; Valdivia Cabrera, Gonzalo Sergio; S/I; 57007
dc.issue.numero10
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final534
dc.pagina.inicio530
dc.publisherELSEVIER ESPANA SLU
dc.revistaARCHIVOS DE BRONCONEUMOLOGIA
dc.rightsregistro bibliográfico
dc.subjectchronic obstructive pulmonary disease (COPD)
dc.subjectbronchodilator response
dc.subjectreference values
dc.subjectspirometry
dc.subjectcross-sectional study
dc.subjectLatin America
dc.subjectPLATINO
dc.subjectDISEASE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSpirometry reference values after inhalation of 200 mu g of Salbutamol
dc.typeartículo
dc.volumen43
sipa.codpersvinculados57007
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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