Cholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile

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dc.catalogadoryvc
dc.contributor.authorMiquel Poblete Juan Francisco
dc.contributor.authorNuñez, Liliana
dc.contributor.authorAmigo Boker, Ludwig Peter
dc.contributor.authorGonzález Bombardiere, Sergio Javier
dc.contributor.authorRaddatz Echavarría, Alejandro
dc.contributor.authorRigotti Rivera, Attilio Gianpietro
dc.contributor.authorNervi Oddone, Flavio
dc.date.accessioned2024-08-08T20:01:07Z
dc.date.available2024-08-08T20:01:07Z
dc.date.issued1998
dc.description.abstractBiliary proteins are promoters of cholesterol crystallization in artificial model bile. However, their pathogenic importance for cholesterol precipitation in native gallbladder bile (GB) is uncertain. The aim of this study was to evaluate the significance of biliary lipids and proteins on cholesterol crystal detection time (ChCDT) of GB in patients with gallstones. Methods: ChCDT and concentrations of lipids, albumin, mucins, aminopeptidase N, alpha 1-acid glycoprotein, haptoglobin, and immunoglobulins (Igs) were measured in GB of 92 patients, 52 of whom had cholesterol gallstones. Results: ChCDT was markedly reduced in gallstone patients. Compared with patients without gallstones, they had a significant increase in cholesterol saturation and total protein, albumin, mucin, and IgG biliary concentrations. In univariate analysis, ChCDT of GB was significantly correlated with cholesterol saturation and total lipid, protein, Ig, aminopeptidase N, and alpha 1-acid glycoprotein concentrations. However, stepwise logistic regression analysis showed that only cholesterol saturation independently correlated to ChCDT. Gallbladder inflammation correlated with the concentration of Igs, but subtraction of IgG from GB did not modify the ChCDT. Conclusions: Biliary cholesterol transport and saturation, but not proteins, appear critical for the cholesterol crystallization abnormality observed in native bile from patients with gallstones.
dc.fechaingreso.objetodigital2024-08-08
dc.format.extent8 páginas
dc.fuente.origenWoS
dc.identifier.doi10.1016/S0016-5085(98)70322-1
dc.identifier.issn0016-5085
dc.identifier.pubmedidMedline_ID: 9558292
dc.identifier.urihttps://doi.org/10.1016/S0016-5085(98)70322-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87372
dc.identifier.wosidWOS:000073256500025
dc.information.autorucEscuela de Medicina; Miquel Poblete, Juan Francisco; 0000-0002-0526-4377; 72216
dc.information.autorucEscuela de Medicina; Amigo Boker, Ludwig Peter; S/I; 62028
dc.information.autorucEscuela de Medicina; González Bombardiere, Sergio Javier; S/I; 35015
dc.information.autorucEscuela de Medicina; Raddatz Echavarría, Alejandro; S/I; 99184
dc.information.autorucEscuela de Medicina; Rigotti Rivera, Attilio Gianpietro; 0000-0002-0495-3525; 68489
dc.information.autorucEscuela de Medicina; Nervi Oddone, Flavio; 0000-0002-6642-7985; 99156
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1023
dc.pagina.inicio1016
dc.publisherW. B. Saunders Co.
dc.revistaGastroenterology
dc.rightsacceso restringido
dc.subjectBiliary Alpha(1)-Acid Glycoprotein
dc.subjectAminopeptidase-N
dc.subjectGallstone Formation
dc.subjectPromoting Activity
dc.subjectDeoxycholic-Acid
dc.subjectPhospholipase-C
dc.subjectBinding Protein
dc.subjectNucleation Time
dc.subjectModel Biles
dc.subjectPrairie Dog
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile
dc.typeartículo
dc.volumen114
sipa.codpersvinculados72216
sipa.codpersvinculados62028
sipa.codpersvinculados35015
sipa.codpersvinculados99184
sipa.codpersvinculados68489
sipa.codpersvinculados99156
sipa.trazabilidadWOS;05-06-2021
sipa.trazabilidadHistorial Académico;09-07-2021
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