Mild hypothermia does not affect liver regeneration after partial hepatectomy in mice

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dc.contributor.authorPablo Arab, Juan
dc.contributor.authorPizarro, Margarita
dc.contributor.authorSolis, Nancy
dc.contributor.authorSun, Hongdan
dc.contributor.authorThevananther, Sundararajah
dc.contributor.authorArrese, Marco
dc.date.accessioned2024-01-10T13:14:51Z
dc.date.available2024-01-10T13:14:51Z
dc.date.issued2009
dc.description.abstractThe use of mild hypothermia has been suggested to be therapeutically useful in treating acute liver failure. It is not known if hypothermia influences liver regeneration.
dc.description.abstractTo assess the effect of hypothermia on liver regeneration in mice.
dc.description.abstractAfter partial (70%) hepatectomy (PHx), C57BL6/J mice were randomly assigned to either a hypothermic group or a normothermic group. Controlled mild hypothermia was maintained for up to 3 h after surgery. In addition, assessment of liver mass restitution was examined by studying the induction of key cell cycle proteins (cyclin A, D1 and E) and hepatocyte proliferation [assessment of proliferating cell nuclear antigen (PCNA) protein expression] by Western blotting and DNA synthesis by measuring 5-bromo-2-deoxyuridine (BrdU) incorporation by immunohistochemical techniques 45 h after PHx.
dc.description.abstractPartial hepatectomy induced a vigorous proliferative response in the remnant livers of both groups of mice (normothermic and hypothermic groups), as evidenced by the induction of key cyclins, PCNA and incorporation of BrdU after PHx. The liver/body weight ratio and both cyclin and PCNA protein expression as well as BrdU incorporation did not differ between the regenerating livers of hypothermic and normothermic groups.
dc.description.abstractMild hypothermia does not influence liver regeneration in mice.
dc.description.funderFondo Nacional De Ciencia y Tecnologia de Chile (Fondecyt)
dc.description.funderNational Institute of Health
dc.description.funderNATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent5 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1478-3231.2008.01834.x
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.pubmedidMEDLINE:18662277
dc.identifier.urihttps://doi.org/10.1111/j.1478-3231.2008.01834.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78447
dc.identifier.wosidWOS:000263046600006
dc.information.autorucMedicina;Arab J;S/I;132745
dc.information.autorucMedicina;Arrese M;S/I;76095
dc.information.autorucMedicina;Pizarro M;S/I;102250
dc.information.autorucMedicina;Solís N;S/I;102379
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final348
dc.pagina.inicio344
dc.publisherWILEY
dc.revistaLIVER INTERNATIONAL
dc.rightsacceso restringido
dc.subjectacute liver failure
dc.subjectcell cycle
dc.subjectliver transplantation
dc.subjectINTRACRANIAL-PRESSURE
dc.subjectFAILURE
dc.subjectINJURY
dc.subjectMANAGEMENT
dc.subjectMODELS
dc.subjectRAT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMild hypothermia does not affect liver regeneration after partial hepatectomy in mice
dc.typeartículo
dc.volumen29
sipa.codpersvinculados132745
sipa.codpersvinculados76095
sipa.codpersvinculados102250
sipa.codpersvinculados102379
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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