11 beta-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activity

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dc.article.number106217
dc.contributor.authorMosso, L
dc.contributor.authorCarvajal, C
dc.contributor.authorCampino, C
dc.contributor.authorRojas, A
dc.contributor.authorGonzalez, A
dc.contributor.authorBarraza, A
dc.contributor.authorMontero, J
dc.contributor.authorFardella, C
dc.contributor.otherNCD Risk Factor Collaboration (NCD-RisC)
dc.date.accessioned2024-08-15T08:00:24Z
dc.date.available2024-08-15T08:00:24Z
dc.date.issued2002
dc.description.abstractBackground: Half of hypertensive patients with, low plasma renin activity have a primary hyperaldosteronism. Among the remaining half 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) deficiency plays all important role. This enzyme catalyzes the conversion of cortisol to cortisone, avoiding the interaction of cortisol with, the mineralocorticoid receptor. If the enzyme fails, cortisol will stimulate sodium and water reabsorption and increase blood pressure. Aim: To determine biochemical alterations, suggestive of 11betaSHSD2 deficiency, in low-renin hypertensive patients. Patients and Methods: Twenty eight hypertensive patients with a plasma renin activity of less than 0.5 ug/ml/h and with a plasma aldosterone of less than 5 ng/dl were studied. Twenty eight normotensive patients were studied as controls. Serum. cortisol (RIA), cortisone (ELISA) and the serum cortisol/cortisone ratio were determined in all of them, between, 9 and 10 AM. Measurements were confirmed by high pressure liquid chromatography. The serum cortisol/cortisone ratio was considered abnormal when its Ln (cortisol/cortisone) value was over 2 standard deviations of the mean. Results: Serum cortisol was higher in hypertensive subjects than in controls (11.1 +/- 3.3 and 9.2 +/- 2.8 mug/dl, respectively; p <0.05). No differences were observed in serum cortisone (3.4 +/- 1.3 and 3.7 +/- 1.2 &mu;g/dl, respectively). Four hypertensive subjects bad all abnormally high Ln (cortisol/cortisone) value (1.86; 1.73; 2.07 and 2.01, considering a normal value of less than 1.61). Conclusions: Four of 28 hypertensive subjects with, low plasma renin activity and aldosterone had biochemical alterations suggestive of 11.1&beta;HSD2 deficiency.
dc.description.funderANID through FONDECYT
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1161/01.HYP.34.4.779
dc.identifier.eissn1524-4563
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:12587501
dc.identifier.scopusidSCOPUS_ID:0346985951
dc.identifier.urihttps://doi.org/10.1161/01.HYP.34.4.779
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87468
dc.identifier.wosidWOS:000180211200001
dc.information.autorucFacultad de Medicina; Mosso Gomez, Lorena Montserrat; S/I; 88201
dc.issue.numero11
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1208
dc.pagina.inicio1201
dc.relation.ispartof92nd Meeting and Expo of the Endocrine Society (ENDO 2010), JUN 19-22, 2010, San Diego, CA
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsregistro bibliográfico
dc.subjectaldosterone
dc.subjecthypertension
dc.subjectrenin-angiotensin system
dc.subject11 beta-hydroxysteroid dehydrogenases
dc.subjectAPPARENT MINERALOCORTICOID EXCESS
dc.subjectPRIMARY HYPERALDOSTERONISM
dc.subjectGLUCOCORTICOID RECEPTOR
dc.subjectBIOCHEMICAL PHENOTYPE
dc.subjectMOLECULAR-BIOLOGY
dc.subjectTYPE-2 GENE
dc.subjectMETABOLISM
dc.subjectMUTATIONS
dc.subjectGENOTYPE
dc.subjectCORTISOL
dc.subject.ddc550
dc.subject.deweyCiencias de la tierraes_ES
dc.title11 beta-hydroxysteroid dehydrogenase activity in patients with hypertension and low plasma renin activity
dc.typeartículo
dc.volumen130
sipa.codpersvinculados88201
sipa.indexWOS
sipa.indexPubmed
sipa.trazabilidadCarga WOS-SCOPUS;15-08-2024
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