Biomedical Applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches

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dc.catalogadorjca
dc.contributor.authorKaur, Jaskiran
dc.contributor.authorGulati, Monica
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorDureja, Harish
dc.contributor.authorLoebenberg, Raimar
dc.contributor.authorAnsari, Md Salahuddin
dc.contributor.authorAlOmeir, Othman
dc.contributor.authorAlam, Aftab
dc.contributor.authorChellappan, Dinesh Kumar
dc.contributor.authorGupta, Gaurav
dc.contributor.authorJha, Niraj Kumar
dc.contributor.authorPinto, Terezinha de Jesus Andreoli
dc.contributor.authorMorris, Andrew
dc.contributor.authorChoonara, Yahya E.
dc.contributor.authorAdams, Jon
dc.contributor.authorDua, Kamal
dc.contributor.authorSingh, Sachin Kumar
dc.date.accessioned2023-08-25T19:49:12Z
dc.date.available2023-08-25T19:49:12Z
dc.date.issued2022
dc.description.abstractIntroduction Diabetes mellitus (DM) is the most common metabolic disease and multifactorial, harming patients worldwide. Extensive research has been carried out in the search for novel drug delivery systems offering reliable control of glucose levels for diabetics, aiming at efficient management of DM. Areas covered Polymeric micelles (PMs) as smart drug delivery nanocarriers are discussed, focusing on oral drug delivery applications for the management of hyperglycemia. The most recent approaches used for the preparation of smart PMs employ molecular features of amphiphilic block copolymers (ABCs), such as stimulus sensitivity, ligand conjugation, and as a more specific example the ability to inhibit islet amyloidosis. Expert opinion PMs provide a unique platform for self-regulated or spatiotemporal drug delivery, mimicking the working mode of pancreatic islets to maintain glucose homeostasis for prolonged periods. This unique characteristic is achieved by tailoring the functional chemistry of ABCs considering the physicochemical traits of PMs, including sensing capabilities, hydrophobicity, etc. In addition, the application of ABCs for the inhibition of conformational changes in islet amyloid polypeptide garnered attention as one of the root causes of DM. However, research in this field is limited and further studies at the clinical level are required.
dc.fechaingreso.objetodigital2023-08-25
dc.fuente.origenWOS
dc.identifier.doi10.1080/17425247.2022.2087629
dc.identifier.eissn1744-7593
dc.identifier.issn1742-5247
dc.identifier.urihttps://doi.org/10.1080/17425247.2022.2087629
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74502
dc.identifier.wosidWOS:000814114500001
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaExpert Opinion on Drug Delivery
dc.rightsacceso restringido
dc.subjectAmphiphilic block copolymers
dc.subjectMicelles
dc.subjectDiabetes mellitus
dc.subjectDrug delivery
dc.subjectInsulin
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBiomedical Applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches
dc.typereseña
sipa.codpersvinculados1011127
sipa.indexWOS
sipa.trazabilidadWOS;2022-07-08
sipa.trazabilidadORCID;2023-08-21
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