Rat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity

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dc.contributor.authorBorzone, Gisella
dc.contributor.authorLiberona, Leonel
dc.contributor.authorOlmos, Pablo
dc.contributor.authorSaez, Claudia
dc.contributor.authorMeneses, Manuel
dc.contributor.authorReyes, Tatiana
dc.contributor.authorMoreno, Rodrigo
dc.contributor.authorLisboa, Carmen
dc.date.accessioned2024-01-10T14:21:31Z
dc.date.available2024-01-10T14:21:31Z
dc.date.issued2007
dc.description.abstractSyrian Golden hamsters develop severe emphysema after a single intratracheal dose of elastase, whereas Sprague- Dawley rats exhibit mild emphysema with the same dose per kilogram body weight. We hypothesized that the development of severe emphysema is prevented in rats by the high serum level of alpha 1- antitrypsin reported in rats, compared with hamsters, which provides for a high lung elastase inhibitory capacity ( EIC). To explore this possibility, we challenged the antiprotease system of the rats by treating them with three similar weekly doses of elastase. Four months after treatment, we evaluated changes in histology, volume, and elastic properties of rat lungs and compared them with those of hamsters receiving a single dose of elastase. We also measured serum alpha 1- antitrypsin levels and serum and lung EIC in control rats and hamsters. Results showed that, in association with 40% less serum and lung EIC compared with rats ( P < 0.001), hamster lungs had upperlobe bullae formation, severe microscopic emphysema, a fourfold increase in lung volume ( P < 0.01) and a threefold increase in constant k, an index of compliance, of the lung deflation pressurevolume curve ( P < 0.01). In contrast, rats developed mild emphysema, with only 50% increase in volume ( P < 0.05) and 60% increase in constant k ( P < 0.01). In conclusion, two species that differ in serum and lung EIC exhibit significant differences in emphysema development after elastase. Rats with high EIC, despite receiving three doses of elastase, showed significantly less derangement of morphological and physiological parameters than hamsters with low EIC receiving a single dose.
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1152/ajpregu.00343.2007
dc.identifier.eissn1522-1490
dc.identifier.issn0363-6119
dc.identifier.pubmedidMEDLINE:17634200
dc.identifier.urihttps://doi.org/10.1152/ajpregu.00343.2007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79690
dc.identifier.wosidWOS:000249156000049
dc.information.autorucMedicina;Borzone G;S/I;99892
dc.information.autorucMedicina;Lisboa C;S/I;98551
dc.information.autorucMedicina;Olmos P;S/I;98949
dc.information.autorucMedicina;Sáez C;S/I;102375
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherAMER PHYSIOLOGICAL SOC
dc.revistaAMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
dc.rightsacceso restringido
dc.subjectalpha1-antitrypsin
dc.subjectdisease models
dc.subjectlung mechanics
dc.subjectsusceptibility
dc.subjectVOLUME REDUCTION SURGERY
dc.subjectSMOKE-EXPOSED MICE
dc.subjectCIGARETTE-SMOKE
dc.subjectALPHA(1)-PROTEINASE INHIBITOR
dc.subjectANIMAL-MODELS
dc.subjectLUNG DAMAGE
dc.subjectDEFICIENCY
dc.subjectDIAPHRAGM
dc.subjectBLEOMYCIN
dc.subjectADAPTATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRat and hamster species differences in susceptibility to elastase-induced pulmonary emphysema relate to differences in elastase inhibitory capacity
dc.typeartículo
dc.volumen293
sipa.codpersvinculados99892
sipa.codpersvinculados98551
sipa.codpersvinculados98949
sipa.codpersvinculados102375
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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