Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation

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dc.contributor.authorMassardo, L.
dc.contributor.authorMetz, C.
dc.contributor.authorPardo, E.
dc.contributor.authorMezzano, V.
dc.contributor.authorBabul, M.
dc.contributor.authorJarpa, E.
dc.contributor.authorGuzman, A. M.
dc.contributor.authorAndre, S.
dc.contributor.authorKaltner, H.
dc.contributor.authorGabius, H. J.
dc.contributor.authorJacobelli, S.
dc.contributor.authorGonzalez, A.
dc.contributor.authorSoza, A.
dc.date.accessioned2024-01-10T12:04:25Z
dc.date.available2024-01-10T12:04:25Z
dc.date.issued2009
dc.description.abstractThe role of autoantibodies in the pathogenesis of systemic lupus erythematosus (SLE) has not been completely defined. From more than a hundred autoantibodies described in SLE, relatively few have been associated with clinical manifestations. The glycan-binding proteins of the galectin family can modulate the immune system. Anti-galectin autoantibodies thus could have functional and/or pathogenic implications in inflammatory processes and autoimmunity. We previously reported function-blocking autoantibodies against galectin-8 (Gal-8) in SLE. Here we tested these autoantibodies against a series of other human galectins and demonstrated their specificity for Gal-8, being detectable in 23% of 78 SLE patients. Remarkably, they associated with lymphopenia (50% of 18 anti-Gal-8-positive versus 18% of 60 anti-Gal-8-negativecases, Fisher's Exact test two-tailed: P < 0.012). Lymphopenia is a common clinical manifestation in SLE, yet of unknown mechanism. In addition, six of eight patients with both lymphopenia and malar rash had anti-Gal-8 in their sera. Occurrence of these autoantibodies was not confined to SLE as we also found them in sera of patients with rheumatoid arthritis (16%) and septicemia (20%). This study thus establishes occurrence of specific anti-Gal-8 autoantibodies in autoimmune rheumatic diseases and in acute inflammation, with an apparent association to a clinical subset in SLE. Lupus (2009) 18, 539-546.
dc.fechaingreso.objetodigital2024-05-20
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/0961203308099973
dc.identifier.eissn1477-0962
dc.identifier.issn0961-2033
dc.identifier.pubmedidMEDLINE:19395456
dc.identifier.urihttps://doi.org/10.1177/0961203308099973
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75790
dc.identifier.wosidWOS:000266265000009
dc.information.autorucMedicina;Babul M;S/I;8096
dc.information.autorucMedicina;González A;S/I;52306
dc.information.autorucMedicina;Guzmán AM;S/I;77951
dc.information.autorucMedicina;Iacobelli S;S/I;98345
dc.information.autorucMedicina;Massardo L;S/I;100068
dc.information.autorucMedicina;Metz C;S/I;65286
dc.information.autorucMedicina;Soza A;S/I;129570
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final546
dc.pagina.inicio539
dc.publisherSAGE PUBLICATIONS LTD
dc.revistaLUPUS
dc.rightsacceso restringido
dc.subjectautoantibodies
dc.subjectgalectin-8
dc.subjectlymphopenia
dc.subjectSLE
dc.subjectP-PROTEIN ANTIBODIES
dc.subjectJURKAT T-CELLS
dc.subjectDISEASE-ACTIVITY
dc.subjectLIVING CELLS
dc.subjectNEUROPSYCHIATRIC MANIFESTATIONS
dc.subjectANTI-GALECTIN-1 AUTOANTIBODIES
dc.subjectCELLULAR DYSFUNCTION
dc.subjectBINDING PROTEINS
dc.subjectSLE PATIENTS
dc.subjectAPOPTOSIS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAutoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation
dc.typeartículo
dc.volumen18
sipa.codpersvinculados8096
sipa.codpersvinculados52306
sipa.codpersvinculados77951
sipa.codpersvinculados98345
sipa.codpersvinculados100068
sipa.codpersvinculados65286
sipa.codpersvinculados129570
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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