Insulin resistance parameters in children born very preterm and adequate for gestational age

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dc.contributor.authorGarcia, Hernan
dc.contributor.authorLoureiro, Carolina
dc.contributor.authorPoggi, Helena
dc.contributor.authorD'Apremont, Ivonne
dc.contributor.authorMoore, Rosario
dc.contributor.authorOssa, Jose Tomas
dc.contributor.authorBruera, Maria Jose
dc.contributor.authorPeredo, Soledad
dc.contributor.authorCarvajal, Jacqueline
dc.contributor.authorTrincado, Claudia
dc.contributor.authorMartinez Aguayo, Alejandro
dc.date.accessioned2024-01-10T12:37:07Z
dc.date.available2024-01-10T12:37:07Z
dc.date.issued2022
dc.description.abstractBackground Preterm neonates are at risk for metabolic syndrome later in life. Whether prematurity constitutes an independent risk factor for the development of cardiovascular disease and metabolic syndrome remains controversial. Objective To compare anthropometric measures, cardiometabolic risk factors and insulin resistance variables between children who were born very preterm (VPT, <32 gestational weeks) and at term (Term, >37 gestational weeks) and adequate for gestational age (AGA). Methods We designed a cross-sectional cohort study, recruiting 120 children (5.0-8.5 years old) from the preterm clinic at Red de Salud UC-Christus and Complejo Asistencial Dr. Sotero del Rio, and term children from the community. We excluded children born small for gestational age, based on INTERGROWTH21. Anthropometrics data were classified using WHO reference standards. The homeostasis model assessment insulin resistance (HOMA-IR) index, quantitative insulin sensitivity check index (QUICKI), triglyceride-to-HDL-C ratio (TG/HDL-C) and Pediatric Score Index for Metabolic Syndrome (PsiMS) were calculated. Results VPT children born AGA had lower HDL cholesterol levels (p = .019) and a higher PsiMS score than those born at term (p = .043). We observed a higher percentage of children with HDL cholesterol <= 40 mg/dl (13.0% vs. 2.3%, p = .026) and BP >= 90th percentile among the VPT children than among the Term children (26.0% vs. 11.6%, p = .031). Conclusions At school age, blood pressure was higher, and HDL-C was lower among VPT children born AGA, suggesting a potential metabolic risk; therefore, it is essential to follow this group throughout their lives.
dc.description.funderFondo de Fomento al Desarrollo Cientifico y Tecnologico
dc.fechaingreso.objetodigital04-04-2024
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/edm2.329
dc.identifier.eissn2398-9238
dc.identifier.pubmedidMEDLINE:35194980
dc.identifier.urihttps://doi.org/10.1002/edm2.329
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76755
dc.identifier.wosidWOS:000759468400001
dc.information.autorucFacultad de Medicina; Martinez Aguayo, Alejandro Gregorio; S/I; 1003862
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherWILEY
dc.revistaENDOCRINOLOGY DIABETES & METABOLISM
dc.rightsacceso abierto
dc.subjectHOMA
dc.subjectinsulin resistance
dc.subjectmetabolic syndrome
dc.subjectpremature
dc.subjectPsiMS
dc.subject3RD NATIONAL-HEALTH
dc.subjectMETABOLIC SYNDROME
dc.subjectBIRTH
dc.subjectSENSITIVITY
dc.subjectPREVALENCE
dc.subjectPREMATURITY
dc.subjectASSOCIATION
dc.subjectADOLESCENTS
dc.subjectCOMPONENTS
dc.subjectCHILDHOOD
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleInsulin resistance parameters in children born very preterm and adequate for gestational age
dc.typeartículo
sipa.codpersvinculados1003862
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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