Helicobacter pylori -induced chronic gastritis and assessing risks for gastric cancer

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dc.article.number393015
dc.catalogadorgjm
dc.contributor.authorCarrasco, Gonzalo
dc.contributor.authorCorvalán R., Alejandro
dc.date.accessioned2024-06-04T16:19:14Z
dc.date.available2024-06-04T16:19:14Z
dc.date.issued2013
dc.description.abstractChronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the role of HP in the multistep cascade of GC. We attempt to define the role of the Operative Link for Gastritis Assessment (OLGA) staging system in assessing the risk of GC. The epigenetic bases of chronic gastritis, mainly DNA methylation, are presented through examples such as (i) the methylation of the promoter region of E-cadherin in HP-induced chronic gastritis and its reversion after HP eradication and (ii) the association of methylation of the promoter region of Reprimo, a p53-mediated cell cycle arrest gene, with aggressive HP strains in high risk areas for GC. In addition, we discuss the finding of RPRM as a circulating cell-free DNA, offering the opportunity for noninvasive risk assessment of GC. Finally, the integration of OLGA and tissue biomarkers, by systems pathology approach, suggests that severe atrophy has a greater risk for GC development if, in addition, overexpressed p73. This trial is registered with ClinicalTrials.gov NCT01774266.
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-06-04
dc.format.extent9 páginas
dc.fuente.origenHistorial Académico
dc.identifier.citationCarrasco G, Corvalan A. Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer. Gastroenterology Research And Practice. 2013;(393015):1-5.
dc.identifier.doi10.1155/2013/393015
dc.identifier.issn1687-6121
dc.identifier.urihttp://dx.doi.org/10.1155/2013/393015
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86390
dc.identifier.wosidWOS:000323075500001
dc.information.autorucEscuela de Medicina; Corvalán R., Alejandro; 0000-0001-5492-3853; 63885
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaGastroenterology Research and Practice
dc.rightsacceso abierto
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHelicobacter pylori -induced chronic gastritis and assessing risks for gastric cancer
dc.typeartículo de revisión
dc.volumen2013
sipa.codpersvinculados63885
sipa.trazabilidadHistorial Académico;09-07-2021
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