Systemic and Pulmonary Inflammation/Oxidative Damage: Implications of General and Respiratory Muscle Training in Chronic Spinal-Cord-Injured Patients

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dc.article.number828
dc.catalogadorgjm
dc.contributor.authorAraneda, Oscar F.
dc.contributor.authorRosales-Antequera, Cristián
dc.contributor.authorContreras Briceño, Felipe
dc.contributor.authorTuesta, Marcelo
dc.contributor.authorRossi-Serrano, Rafael
dc.contributor.authorMagalhães, José
dc.contributor.authorViscor, Ginés
dc.date.accessioned2023-06-19T16:18:14Z
dc.date.available2023-06-19T16:18:14Z
dc.date.issued2023
dc.description.abstractChronic spinal cord injury affects several respiratory-function-related parameters, such as a decrease in respiratory volumes associated with weakness and a tendency to fibrosis of the perithoracic muscles, a predominance of vagal over sympathetic action inducing airway obstructions, and a difficulty in mobilizing secretions. Altogether, these changes result in both restrictive and obstructive patterns. Moreover, low pulmonary ventilation and reduced cardiovascular system functionality (low venous return and right stroke volume) will hinder adequate alveolar recruitment and low O2 diffusion, leading to a drop in peak physical performance. In addition to the functional effects described above, systemic and localized effects on this organ chronically increase oxidative damage and tissue inflammation. This narrative review describes both the deleterious effects of chronic spinal cord injury on the functional effects of the respiratory system as well as the role of oxidative damage/inflammation in this clinical context. In addition, the evidence for the effect of general and respiratory muscular training on the skeletal muscle as a possible preventive and treatment strategy for both functional effects and underlying tissue mechanisms is summarized.
dc.fechaingreso.objetodigital2023-06-19
dc.format.extent15 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/biology12060828
dc.identifier.urihttps://www.mdpi.com/2079-7737/12/6/828
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/73492
dc.information.autorucDepartamento de Ciencias de la Salud; Contreras Briceño, Felipe; 0000-0002-0674-7506; 1011730
dc.issue.numero6
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaBiology
dc.rightsacceso abierto
dc.subjectSpinal cord injury
dc.subjectLung
dc.subjectInflammation
dc.subjectOxidative stress
dc.subjectRespiratory muscle training
dc.titleSystemic and Pulmonary Inflammation/Oxidative Damage: Implications of General and Respiratory Muscle Training in Chronic Spinal-Cord-Injured Patients
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1011730
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