High-risk HPV infection after five years in a population-based cohort of Chilean women

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dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorDomínguez, M. A.
dc.contributor.authorPuschel Illanes, Klaus
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorOlcay, Fabiola
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorSnijders, Peter J.
dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorVan De Wyngard, Vanessa
dc.contributor.authorDomínguez, M. A.
dc.contributor.authorPuschel Illanes, Klaus
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorOlcay, Fabiola
dc.contributor.authorFranceschi, Silvia
dc.contributor.authorSnijders, Peter J.
dc.date.accessioned2019-10-17T15:42:15Z
dc.date.available2019-10-17T15:42:15Z
dc.date.issued2011
dc.date.updated2019-10-14T18:51:31Z
dc.description.abstractAbstract Background The need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (HPV): vaccines and screening tests. To consider these innovations, information on HPV type distribution and natural history is necessary. This is a five-year follow-up study of gynecological high-risk (HR) HPV infection among a Chilean population-based cohort of women. Findings A population-based random sample of 969 women from Santiago, Chile aged 17 years or older was enrolled in 2001 and revisited in 2006. At both visits they answered a survey on demographics and sexual history and provided a cervical sample for HPV DNA detection (GP5+/6+ primer-mediated PCR and Reverse line blot genotyping). Follow-up was completed by 576 (59.4%) women; 45 (4.6%) refused participation; most losses to follow-up were women who were unreachable, no longer eligible or had missing samples. HR-HPV prevalence increased by 43%. Incidence was highest in women < 20 years of age (19.4%) and lowest in women > 70 (0%); it was three times higher among women HR-HPV positive versus HPV negative at baseline (25.5% and 8.3%; OR 3.8, 95% CI 1.8-8.0). Type-specific persistence was 35.3%; it increased with age, from 0% in women < 30 years of age to 100% in women > 70. An enrollment Pap result ASCUS or worse was the only risk factor for being HR-HPV positive at both visits. Conclusions HR-HPV prevalence increased in the study population. All HR-HPV infections in women < 30 years old cleared, supporting the current recommendation of HR-HPV screening for women > 30 years.
dc.fuente.origenBiomed Central
dc.identifier.citationInfectious Agents and Cancer. 2011 Nov 16;6(1):21
dc.identifier.doi10.1186/1750-9378-6-21
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26786
dc.issue.numeroNo. 21
dc.language.isoen
dc.pagina.final6
dc.pagina.inicio1
dc.revistaInfectious Agents and Canceres_ES
dc.rightsacceso abierto
dc.rights.holderFerreccio et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherCáncer de cuello uterino - Prevención y controles_ES
dc.subject.otherVirus del Papiloma - Chilees_ES
dc.subject.otherInfecciones bacterianases_ES
dc.titleHigh-risk HPV infection after five years in a population-based cohort of Chilean womenes_ES
dc.typeartículo
dc.volumenVol. 6
sipa.codpersvinculados99684
sipa.codpersvinculados83957
sipa.codpersvinculados63885
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