IL28B Polymorphisms Among Latin American HCV Patients

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dc.contributor.authorSoza, Alejandro
dc.contributor.authorLópez Lastra, Marcelo Andrés
dc.date.accessioned2020-01-14T01:06:50Z
dc.date.available2020-01-14T01:06:50Z
dc.date.issued2013
dc.description.abstractLatin America is a diverse region with more than 500 million people and approximately 8 million HCV infected individuals. The recent description of genetic polymorphisms associated to the interleukin 28B gene that predicts the response to treatment in these patients has impacted the clinical algorithms of management. In this review we examine the studies of prevalence of the IL28B genotypes in the general population and in HCV infected patients in the region and its relationship with treatment response to peginterferon and ribavirin. We show that the prevalence in the different studies in the region show a CC genotype of the rs12979860 between 18 to 35 %. This particular SNP is more consistently associated with treatment response than rs8099917 in Latin America, as well as around the world.
dc.fuente.origenFacultad de Medicina
dc.identifier.doi10.1007/s11901-013-0182-6
dc.identifier.issn1540-3416
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27438
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaCurrent Hepatitis Reportses_ES
dc.rightsacceso restringido
dc.subjectHCVes_ES
dc.subjectHepatitis C viruses_ES
dc.subjectIL28Bes_ES
dc.subjectInterleukin 28Bes_ES
dc.subjectLambda 3es_ES
dc.subjectLatin Americaes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleIL28B Polymorphisms Among Latin American HCV Patientses_ES
dc.typeartículo
sipa.codpersvinculados461
sipa.codpersvinculados84823
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