Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients

Simple item page
dc.catalogadorpau
dc.contributor.authorHernández, P. Glenn
dc.contributor.authorGigoux Muller, Jorge Alberto
dc.contributor.authorBugedo Tarraza, Guillermo
dc.contributor.authorCastillo Fuenzalida, Luis Benito
dc.contributor.authorBruhn Cruz, Alejandro Rodrigo
dc.contributor.authorTomicic, Vinko
dc.contributor.authorDagnino Sepúlveda, Jorge Álvaro
dc.date.accessioned2023-05-18T19:49:47Z
dc.date.available2023-05-18T19:49:47Z
dc.date.issued1999
dc.description.abstractBackground: Vasoactive drugs used in the reanimation of septic patients, can modify splanchnic perfusion. Aim: To compare the effects of dobutamine and amrinone on gastric intramucosal pH (pHi), lactate levels and hemodynamics in surgical patients with compensated septic shock. Patients and methods: Fourteen postoperative patients with abdominal sepsis and compensated septic shock (pHi < 7.32 or lactate > 2.5 mmol/l) were studied in a prospective, randomized, unblinded study. Patients were randomized to receive (Group 1, n = 7) dobutamine at 5 micrograms/Kg/min or (Group 2, n = 7) amrinone at 5 micrograms/Kg/min. Hemodynamic data, arterial lactate and pHi were measured before and 30, 60 and 120 minutes after starting drug infusion. Results: Both drugs were associated with a decrease in lactate levels. Dobutamine infusion, but not amrinone, increased gastric pHi, as well as cardiac index and oxygen delivery. Conclusions: An improvement in gastric pHi associated with an increase in oxygen delivery, was observed with dobutamine. Amrinone showed no effect at the fixed, low dose used in the study.
dc.fuente.origenORCID
dc.identifier.issn0034-9887
dc.identifier.urihttp://www.scopus.com/inward/record.url?eid=2-s2.0-17144434785&partnerID=MN8TOARS
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/67122
dc.information.autorucEscuela de Medicina; Hernández P., Glenn; S/I; 98874
dc.information.autorucEscuela de Medicina; Gigoux Muller, Jorge Alberto; S/I; 3912
dc.information.autorucEscuela de Medicina; Bugedo Tarraza, Guillermo; 0000-0001-7527-6202; 60490
dc.information.autorucEscuela de Medicina; Castillo Fuenzalida, Luis Benito; S/I; 54397
dc.information.autorucEscuela de Medicina; Bruhn Cruz, Alejandro Rodrigo; 0000-0001-8034-1937; 741
dc.information.autorucEscuela de Medicina; Tomicic, Vinko; 0000-0002-6072-4487; 101554
dc.information.autorucEscuela de Medicina; Dagnino Sepúlveda, Jorge Álvaro; 0000-0001-5536-9786; 29778
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaRevista Médica de Chile
dc.rightsacceso restringido
dc.titleAcute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients
dc.title.alternativeEfecto agudo de dobutamina y amrinona sobre la hemodinamia y perfusión esplácnica de pacientes en shock séptico
dc.typeartículo
dc.volumen127
sipa.codpersvinculados98874
sipa.codpersvinculados3912
sipa.codpersvinculados60490
sipa.codpersvinculados54397
sipa.codpersvinculados741
sipa.codpersvinculados101554
sipa.codpersvinculados29778
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients.pdf
Size:
2.66 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas