Infection with SARS-CoV-2 variant Gamma (P.1) in Chile increased ICU admission risk three to five-fold

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dc.catalogadorjwg
dc.contributor.authorSauré, Denis
dc.contributor.authorRizzo, Alessandro
dc.contributor.authorNeira, Ignasi
dc.contributor.authorGoic, Marcel
dc.contributor.authorO’Ryan, Miguel
dc.contributor.authorTorres, Juan P.
dc.contributor.authorBruhn, Alejandro
dc.contributor.authorFerres Garrido, Marcela Viviana
dc.contributor.authorAngulo Troncoso, Jenniffer Alexandra
dc.contributor.authorVera Alarcon, Maria Magdalena
dc.contributor.authorBasso, Leonardo J.
dc.date.accessioned2024-03-14T19:01:12Z
dc.date.available2024-03-14T19:01:12Z
dc.date.issued2023
dc.description.abstractThe 2021 wave of SARS-CoV-2 infection in Chile was characterized by an explosive increase in ICU admissions, which disproportionately affected individuals younger than 60 years. This second wave was also accompanied by an explosive increase in Gamma (P.1) variant detections and the massive vaccine rollout. We unveil the role the Gamma variant played in stressing the use of critical care, by developing and calibrating a queueing model that uses data on new onset cases and actual ICU occupancy, symptom’s onset to ICU admission interval, ICU length-of-stay, genomic surveillance, and vaccine effectiveness. Our model shows that infection with the Gamma (P.1) variant led to a 3.5–4.7-fold increase in ICU admission for people younger than 60 years. This situation occurred on top of the already reported higher infection rate of the Gamma variant. Importantly, our results also strongly suggest that the vaccines used in Chile (inactivated mostly, but also an mRNA), were able to curb Gamma variant ICU admission over infections.
dc.fuente.origenORCID
dc.identifier.doi10.1371/JOURNAL.PONE.0283085
dc.identifier.urihttp://dx.doi.org/10.1371/JOURNAL.PONE.0283085
dc.identifier.urihttps://publons.com/wos-op/publon/51711227/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84435
dc.information.autorucEscuela de Medicina; Vera Alarcon, Maria Magdalena; 0000-0002-2969-3408; 226652
dc.information.autorucEscuela de Medicina; Ferres Garrido Marcela Viviana; 0000-0001-9415-4657; 66180
dc.information.autorucEscuela de Medicina; Angulo Troncoso Jenniffer Alexandra;S/l; 1022740
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaPLoS ONE
dc.rightsacceso abierto
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleInfection with SARS-CoV-2 variant Gamma (P.1) in Chile increased ICU admission risk three to five-fold
dc.typeartículo
dc.volumen18
sipa.codpersvinculados226652
sipa.codpersvinculados66180
sipa.codpersvinculados1022740
sipa.trazabilidadORCID;2024-02-19
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