Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners

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dc.catalogadorjca
dc.contributor.authorContreras Briceño, Felipe
dc.contributor.authorHerrera, Sebastián
dc.contributor.authorVega Adauy, Julián
dc.contributor.authorSalinas, Manuel
dc.contributor.authorOcaranza Jeraldino, María Paz
dc.contributor.authorJalil Milad, Jorge
dc.contributor.authorMandiola Ovalle, Jorge
dc.contributor.authorGarcía, Lorena
dc.contributor.authorChiong, Mario
dc.contributor.authorCastro Galvez, Pablo Federico
dc.contributor.authorLavandero, Sergio
dc.contributor.authorGabrielli Nervi, Luigi Arnaldo
dc.date.accessioned2024-01-23T15:40:13Z
dc.date.available2024-01-23T15:40:13Z
dc.date.issued2021
dc.description.abstractIntroduction: An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated with the development of AF in the general population. However, the relationship between sVCAM-1 and left atrial (LA) remodeling has been poorly investigated in long-distance runners (LDR).Aim: To determine the association between LA remodeling and sVCAM-1 levels in LDR during the training period before a marathon race.Methods: Thirty-six healthy male LDR (37.0 +/- 5.3 years; 174.0 +/- 7.0 height; BMI: 23.8 +/- 2.8; V degrees O-2-peak: 56.5 +/- 7.3 mL center dot kg(-1)center dot min(-1)) were evaluated in this single-blind and cross-sectional study. The LDR were separated into two groups according to previous training levels: high-training (HT) (n = 18) >= 100 km center dot week(-1) and low-training (LT) (n = 18) >= 70 and <100 km center dot week(-1). Also, 18 healthy non-active subjects were included as a control group (CTR). In all participants, transthoracic echocardiography was performed. sVCAM-1 blood levels were measured baseline and immediately finished the marathon race in LDR.Results: HT showed increased basal levels of sVCAM-1 (651 +/- 350 vs. 440 +/- 98 ng center dot mL(-1) CTR, p = 0.002; and vs. 533 +/- 133 ng center dot mL(-1) LT; p = 0.003) and a post-marathon increase (Delta sVCAM-1) (651 +/- 350 to 905 +/- 373 ng center dot mL(-1); p = 0.002), that did not occur in LT (533 +/- 133 to 651 +/- 138 ng center dot mL(-1); p = 0.117). In LDR was a moderate correlation between LA volume and sVCAM-1 level (rho = 0.510; p = 0.001).Conclusions: In male long-distance runners, sVCAM-1 levels are directly associated with LA remodeling. Also, the training level is associated with basal sVCAM-1 levels and changes after an intense and prolonged exercise (42.2 km). Whether sVCAM-1 levels predict the risk of AF in runners remains to be established.
dc.fechaingreso.objetodigital2024-01-23
dc.format.extent8
dc.fuente.origenWOS
dc.identifier.doi10.3389/fcvm.2021.737285
dc.identifier.issn2297-055X
dc.identifier.pubmedidMEDLINE:34790706
dc.identifier.urihttps://doi.org/10.3389/fcvm.2021.737285
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80917
dc.identifier.wosidWOS:000719198300001
dc.information.autorucEscuela de Medicina; Contreras Briceño, Felipe; 0000-0002-0674-7506; 1011730
dc.information.autorucEscuela de Medicina; Vega Adauy, Julián; S/I; 209501
dc.information.autorucEscuela de Medicina; Ocaranza Jeraldino, María Paz; 0000-0002-4915-6378; 1001254
dc.information.autorucEscuela de Medicina; Jalil Milad, Jorge; 0000-0001-6877-2072; 99946
dc.information.autorucEscuela de Medicina; Mandiola Ovalle, Jorge; S/I; 243293
dc.information.autorucEscuela de Medicina; Castro Galvez, Pablo Federico; S/I; 100212
dc.information.autorucEscuela de Medicina; Gabrielli Nervi, Luigi Arnaldo; 0000-0002-1551-7147; 11086
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherFRONTIERS MEDIA SA
dc.revistaFrontiers in Cardiovascular Medicine
dc.rightsacceso abierto
dc.subjectArrhythmias
dc.subjectCardiac remodeling
dc.subjectExercise
dc.subjectSports cardiology
dc.subjectAthletes heart
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCirculating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners
dc.typeartículo
dc.volumen8
sipa.codpersvinculados1011730
sipa.codpersvinculados209501
sipa.codpersvinculados1001254
sipa.codpersvinculados99946
sipa.codpersvinculados243293
sipa.codpersvinculados100212
sipa.codpersvinculados11086
sipa.trazabilidadWOS;18-03-2022
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