The functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance

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dc.catalogadorjca
dc.contributor.authorCaceres-Ayala, Constanza
dc.contributor.authorPautassi, Ricardo M.
dc.contributor.authorAcuña, María José
dc.contributor.authorCerpa Nebott, Waldo
dc.contributor.authorRebolledo, Daniela L.
dc.date.accessioned2024-02-27T16:02:47Z
dc.date.available2024-02-27T16:02:47Z
dc.date.issued2022
dc.description.abstractBackground: Chronic alcohol misuse is associated with alcoholic myopathy, characterized by skeletal muscle weakness and atrophy. Moreover, there is evidence that sports-related people seem to exhibit a greater prevalence of problematic alcohol consumption, especially binge drinking (BD), which might not cause alcoholic myopathy but can negatively impact muscle function and amateur and professional athletic performance. Objective: To review the literature concerning the effects of alcohol consumption on skeletal muscle function and structure that can affect muscle performance. Methodology: We examined the currently available literature (PubMed, Google Scholars) to develop a narrative review summarizing the knowledge about the effects of alcohol on skeletal muscle function and exercise performance, obtained from studies in human beings and animal models for problematic alcohol consumption. Results: Exercise- and sport-based studies indicate that alcohol consumption can negatively affect muscle recovery after vigorous exercise, especially in men, while women seem less affected. Clinical studies and pre-clinical laboratory research have led to the knowledge of some of the mechanisms involved in alcohol-related muscle dysfunction, including an imbalance between anabolic and catabolic pathways, reduced regeneration, increased inflammation and fibrosis, and deficiencies in energetic balance and mitochondrial function. These pathological features can appear not only under chronic alcohol misuse but also in other alcohol consumption patterns. Conclusions: Most laboratory-based studies use chronic or acute alcohol exposure, while episodic BD, the most common drinking pattern in amateur and professional athletes, is underrepresented. Nevertheless, alcohol consumption negatively affects skeletal muscle health through different mechanisms, which collectively might contribute to reduced sports performance.
dc.fuente.origenORCID
dc.identifier.doi10.1080/00952990.2022.2041025
dc.identifier.issn0095-2990
dc.identifier.urihttps://doi.org/10.1080/00952990.2022.2041025
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81340
dc.information.autorucFacultad de Ciencias Biológicas;Cáceres Ayala, Constanza Natalie;S/I;1027854
dc.information.autorucFacultad de Ciencias Biológicas;Acuña, María José; S/I;181470
dc.information.autorucFacultad de Ciencias Biológicas;Cerpa Nebott, Waldo;0000-0001-7344-0144;16584
dc.information.autorucFacultad de Ciencias Biológicas;Rebolledo López, Daniela Victoria;S/I;142327
dc.issue.numero2
dc.language.isoes
dc.nota.accesoContenido parcial
dc.revistaThe American Journal of Drug and Alcohol Abuse
dc.rightsacceso restringido
dc.subjectAlcohol
dc.subjectAlcoholic myopathy
dc.subjectMuscle performance
dc.subjectProblematic alcohol consumption
dc.subjectMuscle pathology
dc.subjectBinge drinking
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe functional and molecular effects of problematic alcohol consumption on skeletal muscle: a focus on athletic performance
dc.typeartículo
dc.volumen48
sipa.codpersvinculados1027854
sipa.codpersvinculados181470
sipa.codpersvinculados16584
sipa.codpersvinculados142327
sipa.trazabilidadORCID;2024-01-15
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