Infantile Takayasu: clinical features and long-term outcome

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dc.article.numberkeac691
dc.catalogadorjca
dc.contributor.authorMiller-Barmak, Adi
dc.contributor.authorSztajnbok, Flavio
dc.contributor.authorBalik, Zeynep
dc.contributor.authorBorzutzky Schachter, Arturo
dc.contributor.authorFogel, Leslie A.
dc.contributor.authorGoldzweig, Ofra
dc.contributor.authorOzen, Seza
dc.contributor.authorAviel, Yonatan Butbul
dc.date.accessioned2023-01-19T13:55:12Z
dc.date.available2023-01-19T13:55:12Z
dc.date.issued2022
dc.description.abstractObjectives: Takayasu arteritis (TAK) is a large-vessel vasculitis rarely reported in children and infants. Most articles on paediatric TAK have not focused on infants. We present the largest case series of infantile TAK, aiming to identify its demographic and clinical characteristics and compare them with existing data on older children. Methods: We conducted an international multicentre retrospective cohort study. Epidemiological and clinical data were collected from patients’ charts from six rheumatology centres. All patients met both the EULAR/PReS 2008 criteria and the 1990 ACR/EULAR criteria and were diagnosed with TAK at age <5 years. Results: Twelve patients were included (50% female). Median age of symptom onset was 11 months, with a diagnostic delay of 4 months. The most common symptoms at presentation were hypertension, blood pressure differences between limbs, and fever. The most commonly involved arteries were the abdominal aorta and renal artery. Medications included steroids, conventional and biologic DMARDs, and other immunosuppressive therapies. Half of the patients received biologic agents, of which infliximab had the highest complete remission rate (40%). Other medications resulting in complete remission were CYC (40%) and MTX (38%). Invasive procedures were required for 58% of patients. The most common complications were cardiac (50%), stroke (42%), and serious infections (33%). No patients died. Conclusion: This study presents the largest series of infantile TAK. Compared with other reported series on older children, infants with TAK have more severe disease and were more likely to receive biologic agents, develop complications, and require invasive interventions.
dc.fechaingreso.objetodigital2023-01-19
dc.fuente.origenSIPA
dc.identifier.doi10.1093/rheumatology/keac691
dc.identifier.eissn1462-0332
dc.identifier.issn1462-0324
dc.identifier.urihttps://doi.org/10.1093/rheumatology/keac691
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66374
dc.information.autorucFacultad de medicina ; Borzutzky Schachter, Arturo ; 0000-0002-7904-262X ; 5897
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final7
dc.pagina.inicio1
dc.revistaRheumatology
dc.rightsacceso abierto
dc.subjectTakayasu arteritis
dc.subjectInfantile
dc.subjectVasculitis
dc.subjectPaediatric
dc.subjectChildren
dc.titleInfantile Takayasu: clinical features and long-term outcome
dc.typeartículo
sipa.codpersvinculados5897
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