Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection

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dc.catalogadorjca
dc.contributor.authorAndrade, Catalina A.
dc.contributor.authorKalergis, Alexis
dc.contributor.authorBohmwald, Karen
dc.date.accessioned2024-02-27T16:02:49Z
dc.date.available2024-02-27T16:02:49Z
dc.date.issued2021
dc.description.abstractRespiratory infections are among the major public health burdens, especially during winter. Along these lines, the human respiratory syncytial virus (hRSV) is the principal viral agent causing acute lower respiratory tract infections leading to hospitalization. The pulmonary manifestations due to hRSV infection are bronchiolitis and pneumonia, where the population most affected are infants and the elderly. However, recent evidence suggests that hRSV infection can impact the mother and fetus during pregnancy. Studies have indicated that hRSV can infect different cell types from the placenta and even cross the placenta barrier and infect the fetus. In addition, it is known that infections during the gestational period can lead to severe consequences for the development of the fetus due not only to a direct viral infection but also because of maternal immune activation (MIA). Furthermore, it has been described that the development of the central nervous system (CNS) of the fetus can be affected by the inflammatory environment of the uterus caused by viral infections. Increasing evidence supports the notion that hRSV could invade the CNS and infect nervous cells, such as microglia, neurons, and astrocytes, promoting neuroinflammation. Moreover, it has been described that the hRSV infection can provoke neurological manifestations, including cognitive impairment and behavioral alterations. Here, we will review the potential effect of hRSV in brain development and the potential long-term neurological sequelae.
dc.fechaingreso.objetodigital2024-04-15
dc.fuente.origenORCID
dc.identifier.doi10.3390/pathogens11010047
dc.identifier.urihttps://doi.org/10.3390/pathogens11010047
dc.identifier.urihttps://www.mdpi.com/2076-0817/11/1/47
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/81353
dc.information.autorucFacultad de Ciencias Biológicas;Andrade, Catalina A.;S/I;234276
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas;Bohmwald, Karen;S/I;1007746
dc.issue.numero11
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final12
dc.pagina.inicio1
dc.revistaPathogens
dc.rightsacceso abierto
dc.subjectHuman respiratory syncytial virus
dc.subjectMaternal immune activation
dc.subjectCentral nervous system
dc.subjectNeurological alterations
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePotential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection
dc.typeartículo
dc.volumen47
sipa.codpersvinculados234276
sipa.codpersvinculados90610
sipa.codpersvinculados1007746
sipa.trazabilidadORCID;2024-01-15
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