Effects of dietary supplementation with EPA and/or -lipoic acid on adipose tissue transcriptomic profile of healthy overweight/obese women following a hypocaloric diet

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dc.contributor.authorHuerta, Ana E.
dc.contributor.authorPrieto Hontoria, Pedro L.
dc.contributor.authorFernandez Galilea, Marta
dc.contributor.authorEscote, Xavier
dc.contributor.authorAlfredo Martinez, J.
dc.contributor.authorMoreno Aliaga, Maria J.
dc.date.accessioned2024-01-10T13:47:53Z
dc.date.available2024-01-10T13:47:53Z
dc.date.issued2017
dc.description.abstractIn obesity, the increment of adiposity levels disrupts the whole body homeostasis, promoting an over production of oxidants and inflammatory mediators. The current study aimed to characterize the transcriptomic changes promoted by supplementation with eicosapentaenoic acid (EPA, 1.3 g/day), -lipoic acid (0.3 g/day), or both (EPA+-lipoic acid, 1.3 g/day+0.3 g/day) in subcutaneous abdominal adipose tissue from overweight/obese healthy women, who followed a hypocaloric diet (30% of total energy expenditure) during ten weeks, by using a microarray approach. At the end of the intervention, a total of 33,297 genes were analyzed using Affymetrix GeneChip arrays. EPA promoted changes in extracellular matrix remodeling gene expression, besides a rise of genes associated with either chemotaxis or wound repair. -Lipoic acid decreased expression of genes related with cell adhesion and inflammation. Furthermore, -lipoic acid, especially in combination with EPA, upregulated the expression of genes associated with lipid catabolism while downregulated genes involved in lipids storage. Together, all these data suggest that some of the metabolic effects of EPA and -lipoic acid could be related to their regulatory actions on adipose tissue metabolism. (c) 2016 BioFactors, 43(1):117-131, 2017
dc.description.funderMinistry of Economy and Competitiveness from the Government of Spain
dc.description.funderNavarra Government (Department of Health)
dc.description.funderUniversity of Navarra-Spain
dc.description.funderCIBERobn
dc.description.funderAsociacion de Amigos de la Universidad de Navarra
dc.fechaingreso.objetodigital03-04-2024
dc.format.extent15 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1002/biof.1317
dc.identifier.eissn1872-8081
dc.identifier.issn0951-6433
dc.identifier.pubmedidMEDLINE:27507611
dc.identifier.urihttps://doi.org/10.1002/biof.1317
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79314
dc.identifier.wosidWOS:000394909300010
dc.information.autorucMedicina; Fernandez M;S/I;242757
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final131
dc.pagina.inicio117
dc.publisherWILEY
dc.revistaBIOFACTORS
dc.rightsacceso restringido
dc.subjectmicroarray
dc.subjectn3-PUFAs
dc.subjectgene expression
dc.subjectadipose tissue
dc.subjectobesity
dc.subjectENDOPLASMIC-RETICULUM STRESS
dc.subjectPOLYUNSATURATED FATTY-ACIDS
dc.subjectEICOSAPENTAENOIC ACID
dc.subjectINSULIN SENSITIVITY
dc.subjectGENE-EXPRESSION
dc.subjectMETABOLIC SYNDROME
dc.subjectWEIGHT-LOSS
dc.subjectOBESITY
dc.subjectINFLAMMATION
dc.subjectMACROPHAGES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of dietary supplementation with EPA and/or -lipoic acid on adipose tissue transcriptomic profile of healthy overweight/obese women following a hypocaloric diet
dc.typeartículo
dc.volumen43
sipa.codpersvinculados242757
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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