Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems

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dc.article.number110048
dc.catalogadorpva
dc.contributor.authorPrasher, Parteek
dc.contributor.authorSharma, Mousmee
dc.contributor.authorSingh, Sachin Kumar
dc.contributor.authorGulati, Monica
dc.contributor.authorJha, Niraj Kumar
dc.contributor.authorGupta, Piyush Kumar
dc.contributor.authorGupta, Gaurav
dc.contributor.authorChellappan, Dinesh Kumar
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorPinto, Terezinha de Jesus Andreoli
dc.contributor.authorChan, Yinghan
dc.contributor.authorLiu, Gang
dc.contributor.authorPaudel, Keshav Raj
dc.contributor.authorHansbro, Philip M.
dc.contributor.authorOliver, Brian Gregory George
dc.contributor.authorDua, Kamal
dc.date.accessioned2023-08-23T19:52:31Z
dc.date.available2023-08-23T19:52:31Z
dc.date.issued2022
dc.description.abstractMucus gel constitutes of heavily cross-linked mucin fibers forming a viscoelastic, dense porous network that coats all the exposed epithelia not covered with the skin. The layer provides protection to the underlying gastrointestinal, respiratory, and female reproductive tracts, in addition to the organs such as the surface of eye by trapping the pathogens, irritants, environmental fine particles, and potentially hazardous foreign matter. However, this property of mucus gel poses a substantial challenge for realizing the localized and sustained drug delivery across the mucosal surfaces. The mucus permeating particles that spare the protective properties of mucus gel improve the therapeutic potency of the drugs aimed at the management of diseases, including sexually transmitted infections, lung cancer, irritable bowel disease, degenerative eye diseases and infections, and cystic fibrosis. As such, the mucoadhesive materials conjugated with drug molecules display a prolonged retention time in the mucosal gel that imparts a sustained release of the deliberated drug molecules across the mucosa. The contemporarily developed mucus penetrating materials for drug delivery applications comprise of a finer size, appreciable hydrophilicity, and a neutral surface to escape the entrapment within the cross-inked mucus fibers. Pertaining to the mucus secretion as a first line of defence in respiratory tract in response to the invading physical, chemical, and biological pathogens, the development of mucus penetrating materials hold promise as a stalwart approach for revolutionizing the respiratory drug delivery paradigm. The present review provides an epigrammatic collation of the mucus penetrating/mucoadhesive materials for achieving a controlled/sustained release of the cargo pharmaceutics and drug molecules across the respiratory mucus barrier.
dc.fechaingreso.objetodigital2023-08-23
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cbi.2022.110048
dc.identifier.eissn1872-7786
dc.identifier.issn0009-2797
dc.identifier.urihttp://doi.org/10.1016/j.cbi.2022.110048
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74477
dc.identifier.wosidWOS:000841136700005
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final14
dc.pagina.inicio1
dc.publisherELSEVIER IRELAND LTD
dc.revistaChemico-Biological Interactionses_ES
dc.rightsacceso restringido
dc.subjectMucus penetrationes_ES
dc.subjectMucoadhesivees_ES
dc.subjectChronic respiratory diseaseses_ES
dc.subjectNanoparticleses_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTargeting mucus barrier in respiratory diseases by chemically modified advanced delivery systemses_ES
dc.typeartículo
dc.volumen365
sipa.codpersvinculados1011127
sipa.indexWOS
sipa.trazabilidadWOS;2022-10-11
sipa.trazabilidadORCID;2023-08-21
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