Apathy, Executive Function, and Emotion Recognition Are the Main Drivers of Functional Impairment in Behavioral Variant of Frontotemporal Dementia

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dc.contributor.authorMusa Salech, Gada
dc.contributor.authorLillo, Patricia
dc.contributor.authorvan der Hiele, Karin
dc.contributor.authorMendez Orellana, Carolina
dc.contributor.authorIbanez, Agustin
dc.contributor.authorSlachevsky, Andrea
dc.date.accessioned2024-01-10T14:22:59Z
dc.date.available2024-01-10T14:22:59Z
dc.date.issued2022
dc.description.abstractBackground: The cognitive and neuropsychiatric deficits present in patients with behavioral variant frontotemporal dementia (bvFTD) are associated with loss of functionality in the activities of daily living (ADLs). The main purpose of this study was to examine and explore the association between the cognitive and neuropsychiatric features that might prompt functional impairment of basic, instrumental, and advanced ADL domains in patients with bvFTD.Methods: A retrospective cross-sectional study was conducted with 27 patients with bvFTD in its early stage (<2 years of evolution) and 32 healthy control subjects. A neuropsychological assessment was carried out wherein measures of cognitive function and neuropsychiatric symptoms were obtained. The informant-report Technology-Activities of Daily Living Questionnaire was used to assess the percentage of functional impairment in the different ADL domains. To identify the best determinants, three separate multiple regression analyses were performed, considering each functional impairment as the dependent variable and executive function, emotion recognition, disinhibition, and apathy as independent variables.Results: For the basic ADLs, a model that explains 28.2% of the variability was found, in which the presence of apathy (beta = 0.33, p = 0.02) and disinhibition (beta = 0.29, p = 0.04) were significant factors. Concerning instrumental ADLs, the model produced accounted for 63.7% of the functional variability, with the presence of apathy (beta = 0.71, p < 0.001), deficits in executive function (beta = -0.36, p = 0.002), and lack of emotion recognition (beta = 0.28, p = 0.017) as the main contributors. Finally, in terms of advanced ADLs, the model found explained 52.6% of the variance, wherein only the presence of apathy acted as a significant factor (beta = 0.59, p < 0.001).Conclusions: The results of this study show the prominent and transverse effect of apathy in the loss of functionality throughout all the ADL domains. Apart from that, this is the first study that shows that the factors associated with loss of functionality differ according to the functional domain in patients with bvFTD in its early stage. Finally, no other study has analyzed the impact of the lack of emotion recognition in the functionality of ADLs. These results could guide the planning of tailored interventions that might enhance everyday activities and the improvement of quality of life.
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3389/fneur.2021.734251
dc.identifier.issn1664-2295
dc.identifier.pubmedidMEDLINE:35095710
dc.identifier.urihttps://doi.org/10.3389/fneur.2021.734251
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80027
dc.identifier.wosidWOS:000748040400001
dc.information.autorucFacultad de Medicina; Mendez Orellana, Carolina Patricia; S/I; 1015155
dc.language.isoen
dc.nota.accesocontenido completo
dc.publisherFRONTIERS MEDIA SA
dc.revistaFRONTIERS IN NEUROLOGY
dc.rightsacceso abierto
dc.subjectfrontotemporal dementia
dc.subjectfunctionality
dc.subjectactivities of daily living
dc.subjectapathy
dc.subjectexecutive function
dc.subjectfunctional impairment
dc.subjectemotion recognition
dc.subjectMILD COGNITIVE IMPAIRMENT
dc.subjectDAILY LIVING QUESTIONNAIRE
dc.subjectSOCIAL COGNITION
dc.subjectINSTRUMENTAL ACTIVITIES
dc.subjectDIAGNOSTIC-CRITERIA
dc.subjectEVERYDAY FUNCTION
dc.subjectDECLINE
dc.subjectVALIDATION
dc.subjectDISEASE
dc.subjectBRAIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleApathy, Executive Function, and Emotion Recognition Are the Main Drivers of Functional Impairment in Behavioral Variant of Frontotemporal Dementia
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1015155
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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