New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry

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dc.catalogadorjwg
dc.contributor.authorVicuña, Lucas
dc.contributor.authorBarrientos, Esteban
dc.contributor.authorNorambuena, Tomás
dc.contributor.authorAlvares, Danilo
dc.contributor.authorGana Ansaldo, Juan Cristóbal
dc.contributor.authorLeiva Yamaguchi, Valeria
dc.contributor.authorMeza, Cristian
dc.contributor.authorLorenzoni Santos, José Guillermo
dc.contributor.authorMericq, Verónica
dc.contributor.authorPereira, Ana
dc.contributor.authorEyheramendy, Susana
dc.date.accessioned2024-01-17T19:06:22Z
dc.date.available2024-01-17T19:06:22Z
dc.date.issued2023
dc.description.abstractBody-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene HLA-DQB3 strongly associated with BMI at 1.5 - 2.5 years old. A variant in the sex-determining gene DMRT1 was associated with the age at adiposity rebound (Age-AR) in girls (P = 9.8 x 10(-9)). BMI was significantly higher in Mapuche than in Europeans between 5.5 and 16.5 years old. Finally, Age-AR was significantly lower (P = 0.004) by 1.94 years and BMI at AR was significantly higher (P = 0.04) by 1.2 kg/m(2), in Mapuche children compared with Europeans.
dc.fechaingreso.objetodigital2024-05-30
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.isci.2023.106091
dc.identifier.eissn2589-0042
dc.identifier.urihttps://doi.org/10.1016/j.isci.2023.106091
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80552
dc.identifier.wosidWOS:000990651700001
dc.information.autorucEscuela de Medicina; Gana Ansaldo Juan Cristobal; 0000-0002-0400-2164; 8726
dc.information.autorucEscuela de Medicina; Lorenzoni Santos Jose Guillermo; ; 80739
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherCELL PRESS
dc.revistaISCIENCE
dc.rightsacceso abierto
dc.subjectGenomics
dc.subjectHealth sciences
dc.subjectHuman genetics
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNew insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry
dc.typeartículo
dc.volumen26
sipa.codpersvinculados8726
sipa.codpersvinculados80739
sipa.trazabilidadWOS;2023-07-06
sipa.trazabilidadORCID;2024-01-08
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