11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension

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dc.contributor.authorCampino, Carmen
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorCornejo, Javiera
dc.contributor.authorSan Martin, Betty
dc.contributor.authorOlivieri, Oliviero
dc.contributor.authorGuidi, Giancesare
dc.contributor.authorFaccini, Giovanni
dc.contributor.authorPasini, Francesco
dc.contributor.authorSateler, Javiera
dc.contributor.authorBaudrand, Rene
dc.contributor.authorMosso, Lorena
dc.contributor.authorOwen, Gareth I.
dc.contributor.authorKalergis, Alexis M.
dc.contributor.authorPadilla, Oslando
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-01-10T13:45:29Z
dc.date.available2024-01-10T13:45:29Z
dc.date.issued2010
dc.description.abstractCortisol availability is modulated by several enzymes: 11 beta-HSD2, which transforms cortisol (F) to cortisone (E) and 11 beta-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5 alpha- and 5 beta-reductase) inactivate cortisol (together with 3 alpha-HSD) to tetrahydrometabolites: 5 alpha THF, 5 beta THF, and THE. The aim was to assess 11 beta-HSD2, 11 beta-HSD1, and 5 beta-reductase activity in hypertensive patients. Free urinary F, E, THF, and THE were measured by HPLC-MS/MS in 102 essential hypertensive patients and 18 normotensive controls. 11 beta-HSD2 enzyme activity was estimated by the F/E ratio, the activity of 11 beta-HSD1 in compare to 11 beta-HSD2 was inferred by the (5 alpha THF + 5 beta THF)/THE ratio and 5 beta-reductase activity assessed using the E/THE ratio. Activity was considered altered when respective ratios exceeded the maximum value observed in the normotensive controls. A 15.7% of patients presented high F/E ratio suggesting a deficit of 11 beta-HSD2 activity. Of the remaining 86 hypertensive patients, two possessed high (5 alpha THF + 5 beta THF)/THE ratios and 12.8% had high E/THE ratios. We observed a high percentage of alterations in cortisol metabolism at pre-receptor level in hypertensive patients, previously misclassified as essential. 11 beta-HSD2 and 5 beta-reductase decreased activity and imbalance of 11 beta-HSDs should be considered in the future management of hypertensive patients.
dc.description.funderFondo Nacional de Investigacion Cientifica y Tecnologica (Fondecyt)
dc.description.funderMillennium Nucleus on Immunology and Immunotherapy
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent9 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12020-009-9269-9
dc.identifier.eissn1559-0100
dc.identifier.issn1355-008X
dc.identifier.pubmedidMEDLINE:19882252
dc.identifier.urihttps://doi.org/10.1007/s12020-009-9269-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79040
dc.identifier.wosidWOS:000273851800013
dc.information.autorucMedicina;Baudrand R;S/I;1024
dc.information.autorucMedicina;Campino C;S/I;99519
dc.information.autorucMedicina;Carvajal CA;S/I;8586
dc.information.autorucMedicina;Fardella CE;S/I;66235
dc.information.autorucCiencias Biológicas;Kalergis AM;S/I;90610
dc.information.autorucMedicina;Mosso L;S/I;88201
dc.information.autorucCiencias Biológicas;Owen GI;S/I;1000459
dc.information.autorucMedicina;Padilla O;S/I;102063
dc.information.autorucMedicina;Sateler J;S/I;16523
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final114
dc.pagina.inicio106
dc.publisherHUMANA PRESS INC
dc.revistaENDOCRINE
dc.rightsacceso restringido
dc.subjectEssential hypertension
dc.subject11 beta-HSD2
dc.subject11 beta-HSD1
dc.subject5 beta-reductase
dc.subjectAPPARENT MINERALOCORTICOID EXCESS
dc.subjectCORTICOSTEROID HORMONE ACTION
dc.subjectRENIN ESSENTIAL-HYPERTENSION
dc.subjectTANDEM MASS-SPECTROMETRY
dc.subjectURINARY FREE CORTISOL
dc.subjectBLOOD-PRESSURE
dc.subject5-ALPHA-REDUCTASE ACTIVITY
dc.subjectREDUCTASE DEFICIENCY
dc.subjectMETABOLIC SYNDROME
dc.subjectSALT SENSITIVITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.title11 beta-hydroxysteroid dehydrogenase type-2 and type-1 (11 beta-HSD2 and 11 beta-HSD1) and 5 beta-reductase activities in the pathogenia of essential hypertension
dc.typeartículo
dc.volumen37
sipa.codpersvinculados1024
sipa.codpersvinculados99519
sipa.codpersvinculados8586
sipa.codpersvinculados66235
sipa.codpersvinculados90610
sipa.codpersvinculados88201
sipa.codpersvinculados1000459
sipa.codpersvinculados102063
sipa.codpersvinculados16523
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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