Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet

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dc.catalogadoryvc
dc.contributor.authorAmigo Boker, Ludwig Peter
dc.contributor.authorQuiñones, Verónica
dc.contributor.authorMardones, Pablo
dc.contributor.authorZanlungo Matsuhiro, Silvana
dc.contributor.authorMiquel Poblete, Juan Francisco
dc.contributor.authorNervi Oddone, Flavio
dc.contributor.authorRigotti Rivera, Attilio Gianpietro
dc.date.accessioned2024-06-06T19:19:46Z
dc.date.available2024-06-06T19:19:46Z
dc.date.issued2000
dc.description.abstractBackground & aimsBecause apolipoprotein E (apoE) is a key cholesterol transport molecule involved in the hepatic uptake of chylomicron cholesterol, it may play a critical role in controlling bile cholesterol elimination and cholesterol gallstone formation induced by dietary cholesterol. To test this hypothesis, we studied biliary lipid secretion and gallstone formation in apoE-deficient mice fed cholesterol-rich diets.MethodsBile lipid outputs and gallstone sequence events were analyzed in apoE-deficient mice fed a high-cholesterol diet or a lithogenic diet compared with control animals.ResultsA high-cholesterol diet increased biliary cholesterol secretion and gallbladder bile cholesterol concentration in wild-type mice; the increase in bile cholesterol secretion was significantly attenuated in apoE-deficient mice. ApoE knockout mice fed a high-cholesterol lithogenic diet had a markedly lower frequency of gallbladder bile cholesterol crystal and gallstone formation than wild-type mice, which was most likely a result of the decreased cholesterol saturation index found in gallbladder bile of apoE-deficient mice.ConclusionsThese results show that apoE expression is an important factor for regulating both biliary secretion of diet-derived cholesterol as well as diet-induced cholesterol gallstone formation in mice.
dc.fuente.origenORCID
dc.identifier.doi10.1016/s0016-5085(00)70147-8
dc.identifier.urihttps://doi.org/10.1016/s0016-5085(00)70147-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86585
dc.information.autorucEscuela de Medicina;Amigo Boker Ludwig Peter;S/I;62028
dc.information.autorucEscuela de Medicina; Zanlungo Matsuhiro, Silvana; 0000-0001-8383-9829; 72650
dc.information.autorucEscuela de Medicina;Miquel Poblete Juan Francisco;0000-0002-0526-4377;72216
dc.information.autorucEscuela de Medicina;Nervi Oddone, Flavio;0000-0002-6642-7985;99156
dc.information.autorucEscuela de Medicina;Rigotti Rivera, Attilio Gianpietro;0000-0002-0495-3525;68489
dc.language.isoen
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleImpaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet
dc.typeartículo
sipa.codpersvinculados72650
sipa.trazabilidadORCID;2024-06-03
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