Inverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-beta

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dc.contributor.authorSerrano, Carolina A.
dc.contributor.authorTalesnik, Eduardo
dc.contributor.authorPena, Alfredo
dc.contributor.authorRollan, Antonio
dc.contributor.authorDuarte, Ignacio
dc.contributor.authorTorres, Javiera
dc.contributor.authorMajerson, Daniela
dc.contributor.authorEinisman, Helly
dc.contributor.authorViviani, Paola
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2024-01-10T12:39:51Z
dc.date.available2024-01-10T12:39:51Z
dc.date.issued2011
dc.description.abstractObjectives We evaluated allergy/hypersensitivity clinical markers and their correlation with Helicobactor pylori infection in children and adults to analyze how early acquisition of H. pylori could modulate allergic disorder expression.
dc.description.abstractPatients and methods H. pylori presence was assessed by the rapid urease test and histology of antrum biopsies in 165 patients. Skin tests, serum IgE, and two clinical allergy questionnaires were performed. Allergy severity was operationally defined using a combined score. Findings were correlated with H. pylori status and cytotoxin-associated gene A presence in pediatric and adult patients. Transforming growth factor beta (TGF-beta) levels were measured by an enzyme-linked immunosorbent assay in serum and gastric biopsies of H. pylori (+) patients.
dc.description.abstractResults H. pylori (-) children had more positive skin tests to a higher number of antigens than H. pylori (+) children (P<0.05). Operationally defined allergy inversely correlates with H. pylori infection in children, but not in adults. The percentage of H. pylori infection was lower in children with severe allergy (32.3%) compared with children with mild allergy (43.4%) or no allergy (64.3%) (P<0.05). Colonization with virulent strains (cytotoxin-associated gene A +) showed a nonsignificant inverse correlation with severity of allergies in pediatric patients. H. pylori-infected children, but not adults, without allergy markers showed increased levels of TGF-b compared with allergic children both in serum and gastric mucosa (P<0.05).
dc.description.abstractConclusion There was a strong inverse correlation between allergy markers and H. pylori infection in pediatric patients associated with elevated levels of TGF-b locally and systemically. H. pylori-associated chronic gastritis might downregulate clinical allergy expression. Eur J Gastroenterol Hepatol 23: 656-663 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
dc.description.funderFONDECYT, Chile
dc.fechaingreso.objetodigital2024-05-22
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MEG.0b013e328347c231
dc.identifier.eissn1473-5687
dc.identifier.issn0954-691X
dc.identifier.pubmedidMEDLINE:21629122
dc.identifier.urihttps://doi.org/10.1097/MEG.0b013e328347c231
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77243
dc.identifier.wosidWOS:000292503100004
dc.information.autorucMedicina;Duarte I ;S/I;98528
dc.information.autorucMedicina;Einisman H ;S/I;16260
dc.information.autorucMedicina;Harris P;S/I;80706
dc.information.autorucMedicina;Majerson D ;S/I;133956
dc.information.autorucMedicina;Pena A ;S/I;75347
dc.information.autorucMedicina;Rollan A;S/I;100118
dc.information.autorucMedicina;Serrano C ;S/I;15296
dc.information.autorucMedicina;Talesnik E ;S/I;99067
dc.information.autorucMedicina;Torres P ;S/I;95391
dc.information.autorucMedicina;Viviani P ;S/I;729
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final663
dc.pagina.inicio656
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaEUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
dc.rightsacceso restringido
dc.subjectallergy
dc.subjectchildren
dc.subjectgastric inflammation
dc.subjectHelicobacter pylori
dc.subjecttransforming growth factor beta
dc.subjectDISEASES
dc.subjectASTHMA
dc.subjectCOLONIZATION
dc.subjectAUTOIMMUNE
dc.subjectMECHANISMS
dc.subjectGASTRITIS
dc.subjectANTRUM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleInverse correlation between allergy markers and Helicobacter pylori infection in children is associated with elevated levels of TGF-beta
dc.typeartículo
dc.volumen23
sipa.codpersvinculados98528
sipa.codpersvinculados16260
sipa.codpersvinculados80706
sipa.codpersvinculados133956
sipa.codpersvinculados75347
sipa.codpersvinculados100118
sipa.codpersvinculados15296
sipa.codpersvinculados99067
sipa.codpersvinculados95391
sipa.codpersvinculados729
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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