Hematologic profile of the fetus with systemic inflammatory response syndrome

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dc.contributor.authorRomero, Roberto
dc.contributor.authorSavasan, Zeynep Alpay
dc.contributor.authorChaiworapongsa, Tinnakorn
dc.contributor.authorBerry, Stanley M.
dc.contributor.authorPedro Kusanovic, Juan
dc.contributor.authorHassan, Sonia S.
dc.contributor.authorYoon, Bo Hyun
dc.contributor.authorEdwin, Samuel
dc.contributor.authorMazor, Moshe
dc.date.accessioned2024-01-10T12:39:20Z
dc.date.available2024-01-10T12:39:20Z
dc.date.issued2012
dc.description.abstractObjective: The fetal inflammatory response syndrome (FIRS) is associated with impending onset of preterm labor/delivery, microbial invasion of the amniotic cavity and increased perinatal morbidity. FIRS has been defined by an elevated fetal plasma interleukin (IL)-6, a cytokine with potent effects on the differentiation and proliferation of hematopoietic precursors. The objective of this study was to characterize the hematologic profile of fetuses with FIRS.
dc.description.abstractStudy design: Fetal blood sampling was performed in patients with preterm prelabor rupture of membranes and preterm labor with intact membranes (n = 152). A fetal plasma IL-6 concentration >= 11 pg/mL was used to define FIRS. Hemoglobin concentration, platelet count, total white blood cell (WBC) count, differential count, and nucleated red blood cell (NRBC) count were obtained. Since blood cell count varies with gestational age, the observed values were corrected for fetal age by calculating a ratio between the observed and expected mean value for gestational age.
dc.description.abstractResults: 1) The prevalence of FIRS was 28.9% (44/152); 2) fetuses with FIRS had a higher median corrected WBC and corrected neutrophil count than those without FIRS (WBC: median 1.4, range 0.3-5.6, vs. median 1.1, range 0.4-2.9, P=0.001; neutrophils: median 3.6, range 0.1-57.5, vs. median 1.8, range 0.2-13.9, P<0.001); 3) neutrophilia (defined as a neutrophil count >95th centile of gestational age) was significantly more common in fetuses with FIRS than in those without FIRS (71%, 30/42, vs. 35%, 37/105; P<0.001); 4) more than two-thirds of fetuses with FIRS had neutrophilia, whereas neutropenia was present in only 4.8% (2/42); 5) FIRS was not associated with detectable changes in hemoglobin concentration, platelet, lymphocyte, monocyte, basophil or eosinophil counts; and 6) fetuses with FIRS had a median corrected NRBC count higher than those without FIRS. However, the difference did not reach statistical significance (NRBC median 0.07, range 0-1.3, vs. median 0.04, range 0-2.3, P=0.06).
dc.description.abstractConclusion: The hematologic profile of the human fetus with FIRS is characterized by significant changes in the total WBC and neutrophil counts. The NRBC count in fetuses with FIRS tends to be higher than fetuses without FIRS.
dc.description.funderPerinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1515/JPM.2011.100
dc.identifier.eissn1619-3997
dc.identifier.issn0300-5577
dc.identifier.pubmedidMEDLINE:21957997
dc.identifier.urihttps://doi.org/10.1515/JPM.2011.100
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77177
dc.identifier.wosidWOS:000300652600003
dc.information.autorucMedicina;Kusanovic J;S/I;1008900
dc.issue.numero1
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final32
dc.pagina.inicio19
dc.publisherWALTER DE GRUYTER GMBH
dc.revistaJOURNAL OF PERINATAL MEDICINE
dc.rightsregistro bibliográfico
dc.subjectCordocentesis
dc.subjectFIRS
dc.subjecthypoxia
dc.subjectinfection
dc.subjectneutrophil
dc.subjectneutrophilia
dc.subjectnucleated red blood cells
dc.subjectneutropenia
dc.subjectpreterm labor
dc.subjectpreterm PROM
dc.subjectwhite blood cell count
dc.subjectRED-BLOOD-CELLS
dc.subjectTUMOR-NECROSIS-FACTOR
dc.subjectPRETERM PREMATURE RUPTURE
dc.subjectCOLONY-STIMULATING FACTOR
dc.subjectFLUID MATRIX METALLOPROTEINASE-8
dc.subjectMONOCYTE CHEMOTACTIC PROTEIN-1
dc.subject2ND-TRIMESTER AMNIOTIC-FLUID
dc.subjectUMBILICAL-CORD PLASMA
dc.subjectWHITE-MATTER LESIONS
dc.subjectINTRAUTERINE INFECTION
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleHematologic profile of the fetus with systemic inflammatory response syndrome
dc.typeartículo
dc.volumen40
sipa.codpersvinculados1008900
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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