Neurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment

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dc.contributor.authorToledo, C.
dc.contributor.authorAndrade, D. C.
dc.contributor.authorDiaz, H. S.
dc.contributor.authorInestrosa, N. C.
dc.contributor.authorDel Rio, R.
dc.date.accessioned2024-01-10T12:06:52Z
dc.date.available2024-01-10T12:06:52Z
dc.date.issued2019
dc.description.abstractHeart failure (HF) is a major public health issue affecting more than 26 million people worldwide. HF is the most common cardiovascular disease in elder population; and it is associated with neurocognitive function decline, which represent underlying brain pathology diminishing learning and memory faculties. Both HF and neurocognitive impairment are associated with recurrent hospitalization episodes and increased mortality rate in older people, but particularly when they occur simultaneously. Overall, the published studies seem to confirm that HF patients display functional impairments relating to attention, memory, concentration, learning, and executive functioning compared with age-matched controls. However, little is known about the molecular mechanisms underpinning neurocognitive decline in HF. The present review round step recent evidence related to the possible molecular mechanism involved in the establishment of neurocognitive disorders during HF. We will make a special focus on cerebral ischemia, neuroinflammation and oxidative stress, Wnt signaling, and mitochondrial DNA alterations as possible mechanisms associated with cognitive decline in HF. Also, we provide an integrative mechanism linking pathophysiological hallmarks of altered cardiorespiratory control and the development of cognitive dysfunction in HF patients.
dc.description.funderFondo de Desarrollo Cientifico y Tecnologico (Fondecyt)
dc.description.funderBasal Center of Excellence in Aging and Regeneration
dc.description.funderspecial grant "Lithium in Health and Disease" from the Sociedad Quimica y Minera de Chile (SQM)
dc.fechaingreso.objetodigital2024-03-18
dc.format.extent17 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s12035-019-01655-0
dc.identifier.eissn1559-1182
dc.identifier.issn0893-7648
dc.identifier.pubmedidMEDLINE:31165973
dc.identifier.urihttps://doi.org/10.1007/s12035-019-01655-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76217
dc.identifier.wosidWOS:000494860800009
dc.information.autorucCiencias Biológicas;Inestrosa NC, Del Rio R.;S/I;99331
dc.issue.numero12
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final8051
dc.pagina.inicio8035
dc.publisherSPRINGER
dc.revistaMOLECULAR NEUROBIOLOGY
dc.rightsacceso restringido
dc.subjectHeart failure
dc.subjectCognitive impairment
dc.subjectAging
dc.subjectCardiorespiratory control
dc.subjectSignal pathway
dc.subjectCEREBRAL-BLOOD-FLOW
dc.subjectADRENERGIC-RECEPTOR ACTIVATION
dc.subjectSYMPATHETIC NERVOUS-SYSTEM
dc.subjectCOGNITIVE IMPAIRMENT
dc.subjectLOCUS-COERULEUS
dc.subjectALZHEIMERS-DISEASE
dc.subjectOXIDATIVE STRESS
dc.subjectELDERLY-PATIENTS
dc.subjectBETA(2)-ADRENERGIC RECEPTOR
dc.subjectMITOCHONDRIAL DYSFUNCTION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeurocognitive Disorders in Heart Failure: Novel Pathophysiological Mechanisms Underpinning Memory Loss and Learning Impairment
dc.typeartículo
dc.volumen56
sipa.codpersvinculados99331
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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