Andes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome

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dc.contributor.authorGodoy, Paula
dc.contributor.authorMarsac, Delphine
dc.contributor.authorStefas, Elias
dc.contributor.authorFerrer, Pablo
dc.contributor.authorTischler, Nicole D.
dc.contributor.authorPino, Karla
dc.contributor.authorRamdohr, Pablo
dc.contributor.authorVial, Pablo
dc.contributor.authorValenzuela, Pablo D. T.
dc.contributor.authorFerres, Marcela
dc.contributor.authorVeas, Francisco
dc.contributor.authorLopez Lastra, Marcelo
dc.date.accessioned2024-01-10T12:04:12Z
dc.date.available2024-01-10T12:04:12Z
dc.date.issued2009
dc.description.abstractHantavirus cardiopulmonary syndrome (HCPS) is a highly pathogenic emerging disease (40% case fatality rate) caused by New World hantaviruses. Hantavirus infections are transmitted to humans mainly by inhalation of virus-contaminated aerosol particles of rodent excreta and secretions. At present, there are no antiviral drugs or immunotherapeutic agents available for the treatment of hantaviral infection, and the survival rates for infected patients hinge largely on early virus recognition and hospital admission and aggressive pulmonary and hemodynamic support. In this study, we show that Andes virus (ANDV) interacts with human apolipoprotein H (ApoH) and that ApoH-coated magnetic beads or ApoH-coated enzyme-linked immunosorbent assay plates can be used to capture and concentrate the virus from complex biological mixtures, such as serum and urine, allowing it to be detected by both immunological and molecular approaches. In addition, we report that ANDV-antigens and infectious virus are shed in urine of HCPS patients.
dc.description.funderEU
dc.description.funderUltra-Sensitive Diagnosis for Emerging Pathogens (USDEP)
dc.description.funderU.S. Public Health Service
dc.description.funderMECESUP-Universidad Andres Bello
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-05-14
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1128/JVI.02409-08
dc.identifier.eissn1098-5514
dc.identifier.issn0022-538X
dc.identifier.pubmedidMEDLINE:19279096
dc.identifier.urihttps://doi.org/10.1128/JVI.02409-08
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75723
dc.identifier.wosidWOS:000265407700031
dc.information.autorucMedicina;Ferres M;S/I;66180
dc.information.autorucMedicina;Godoy P;S/I;113511
dc.information.autorucMedicina;López-Lastra M;S/I;84823
dc.information.autorucMedicina;Marsac D;S/I;146335
dc.information.autorucMedicina;Pino K;S/I;1005654
dc.information.autorucCiencias Biológicas;Ramdohr P;S/I;119722
dc.information.autorucCiencias Biológicas;Valenzuela PDT;S/I;152599
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final5055
dc.pagina.inicio5046
dc.publisherAMER SOC MICROBIOLOGY
dc.revistaJOURNAL OF VIROLOGY
dc.rightsacceso restringido
dc.subjectTO-PERSON TRANSMISSION
dc.subjectMICE PEROMYSCUS-MANICULATUS
dc.subjectPULMONARY SYNDROME
dc.subjectANTIPHOSPHOLIPID SYNDROME
dc.subjectAPOLIPOPROTEIN-H
dc.subjectHANTAAN VIRUS
dc.subjectHUMAN BETA-2-GLYCOPROTEIN-I
dc.subjectPHOSPHOLIPID-BINDING
dc.subjectMOLECULAR EVIDENCE
dc.subjectHEMORRHAGIC-FEVER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAndes Virus Antigens Are Shed in Urine of Patients with Acute Hantavirus Cardiopulmonary Syndrome
dc.typeartículo
dc.volumen83
sipa.codpersvinculados66180
sipa.codpersvinculados113511
sipa.codpersvinculados84823
sipa.codpersvinculados146335
sipa.codpersvinculados1005654
sipa.codpersvinculados119722
sipa.codpersvinculados152599
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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