Oncogenic hypophosphatemic osteomalacia associated with a nasal hemangiopericytoma

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dc.contributor.authorFuentealba, C
dc.contributor.authorPinto, D
dc.contributor.authorBallesteros, F
dc.contributor.authorPacheco, D
dc.contributor.authorBoettiger, O
dc.contributor.authorSoto, N
dc.contributor.authorFernandez, W
dc.contributor.authorGabler, F
dc.contributor.authorGonzales, G
dc.contributor.authorReginato, AJ
dc.date.accessioned2024-01-10T13:15:45Z
dc.date.available2024-01-10T13:15:45Z
dc.date.issued2003
dc.description.abstractWe report a patient with a nasal hemangiopericytoma associated with an oncogenic hypophosphartemic osteomalacia (OHO). This syndrome results from tumor products that decrease renal tubular phosphate resorption, leading to the osteomalacia. This patient presented with classic bone manifestations of osteomalacia and a nasal tumor. Laboratory studies performed before the first resection of the tumor included normal serum calcium, hypophosphatemia due to decreased tubular reabsorption of phosphate, and an undetectable serum 1,25 dihydroxy vitamin D level. Serum parathormone level was normal. Anterior iliac crest bone biopsy showed characteristic signs of osteomalacia that included increased osteoid and delayed mineralization. A partial resection of the nasal tumor was performed. After the first surgery the patient showed detectable serum level of 1,25 dihydroxy vitamin D, and transient normalization of the tubular reabsorption of phosphate. The patient was also treated with phosphate supplements and vitamin D with transient control of her clinical manifestations and improvement of the radiographic signs of osteomalacia.
dc.description.abstractThree months after surgery, the scrum level of 1,25 dihydroxy vitamin D level again became undetectable. After selective embolization of the tumor, followed by an apparent complete tumor resection and postoperative radiation therapy, her hypophosphatemia and decreased phosphate tubular reabsorption persisted. Therefore, biochemical changes associated with hemangiopericytoma induced OHO may persist even after apparent total tumor resection.
dc.description.abstractClinicians should be aware of the oncogenic basis for some osteomalacia, as seen in this patient.
dc.fechaingreso.objetodigital2024-05-02
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/01.rhu.0000101906.15276.ed
dc.identifier.eissn1536-7355
dc.identifier.issn1076-1608
dc.identifier.pubmedidMEDLINE:17043447
dc.identifier.urihttps://doi.org/10.1097/01.rhu.0000101906.15276.ed
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78528
dc.identifier.wosidWOS:000187661100008
dc.information.autorucMedicina;González G;S/I;100244
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final379
dc.pagina.inicio373
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJCR-JOURNAL OF CLINICAL RHEUMATOLOGY
dc.rightsacceso restringido
dc.subjectosteomalacia
dc.subjectoncogenic
dc.subjectosteomalacia
dc.subjecthemangiopericytoma
dc.subjectRICKETS
dc.subjectPHEX
dc.subject1,25-DIHYDROXYVITAMIN-D
dc.subjectRESISTANT
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOncogenic hypophosphatemic osteomalacia associated with a nasal hemangiopericytoma
dc.typeartículo
dc.volumen9
sipa.codpersvinculados100244
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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