Effects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro

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dc.contributor.authorReyes, E. P.
dc.contributor.authorFernandez, R.
dc.contributor.authorLarrain, C.
dc.contributor.authorZapata, P.
dc.date.accessioned2024-01-10T12:05:09Z
dc.date.available2024-01-10T12:05:09Z
dc.date.issued2007
dc.description.abstractSince acetylcholine (ACh) and ATP have been proposed as excitatory co-transmitters at synapses between glomus cells and sensory nerve endings of the carotid body (CB), we tested such hypothesis by studying the effects of combined cholinergic-purinergic block on the chemosensory activity recorded from cat's carotid bodies perfused and/or superfused in vitro. The preparations were bathed with Tyrode's solution, either normoxic (PO2 = 98.5 +/- 13.5 Torr) or hypoxic (PO2 = 31.8 +/- 5.2 Torr), and the frequency of chemosensory impulses (f(x)) was recorded from the carotid (sinus) nerve. Dose-response curves for f(x) increases evoked by intra-stream boluses of acetylcholine, nicotine and ATP were studied. A combination of mecamylamine 2 mu M and suramin 50 mu M, applied through the perfusate or superfusate, suppressed nicotine- and ATP-induced increases in f(x), but the basal chemosensory activity in normoxia and the chemosensory excitation elicited by hypoxic superfusion were preserved, although variably reduced in most preparations. Thus, in spite of the excitatory effects provoked by applying ACh and ATP to the perfused/superfused CB in vitro, a co-release of these substances cannot account entirely for the chemosensory excitation induced by hypoxic stimulation of the CB. (c) 2006 Elsevier B.V. All rights reserved.
dc.fechaingreso.objetodigital09-04-2024
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.resp.2006.07.007
dc.identifier.issn1569-9048
dc.identifier.pubmedidMEDLINE:16959549
dc.identifier.urihttps://doi.org/10.1016/j.resp.2006.07.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/75955
dc.identifier.wosidWOS:000245001500003
dc.information.autorucMedicina;Fernández R;S/I;99858
dc.information.autorucMedicina;Zapata P;S/I;98016
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final22
dc.pagina.inicio17
dc.publisherELSEVIER SCIENCE BV
dc.revistaRESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
dc.rightsacceso restringido
dc.subjectACh
dc.subjectarterial chemoreceptors
dc.subjectATP
dc.subjectcarotid body
dc.subjectcholinergic block
dc.subjectmecamylamine
dc.subjectnicotine
dc.subjectpurinergic block
dc.subjectsuramin
dc.subjectRELEASE
dc.subjectRAT
dc.subjectATP
dc.subjectACETYLCHOLINE
dc.subjectDOPAMINE
dc.subjectBODIES
dc.subjectACH
dc.subjectACTIVATION
dc.subjectMECHANISMS
dc.subjectRECEPTORS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of combined cholinergic-purinergic block upon cat carotid body chemoreceptors in vitro
dc.typeartículo
dc.volumen156
sipa.codpersvinculados99858
sipa.codpersvinculados98016
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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