Real-time fMRI neurofeedback training as a neurorehabilitation approach on depressive disorders : a systematic review of randomized control trials

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dc.contributor.advisorSitaram, Ranganatha
dc.contributor.authorGonzález Méndez, Pamela Patricia
dc.contributor.otherPontificia Universidad Católica de Chile. Escuela de Medicina
dc.date2022-12-12
dc.date.accessioned2021-12-10T19:45:02Z
dc.date.issued2021
dc.date.updated2021-12-07T00:15:24Z
dc.descriptionTesis (Magíster en Ciencias de la Salud)--Pontificia Universidad Católica de Chile, 2021
dc.description.abstractQuestion: Real-time functional magnetic resonance imaging neurofeedback (rt-fMRI-nf) training is an emerging intervention with potential to neurorehabilitation. We aim to evaluate the evidence of randomized control trials on the clinical application of rt-fMRI-nf training on participants with clinical depression. Study selection and analysis: We searched in Pubmed, Embase, CENTRAL, rtFIN database, Epistemonikos, trial registers, reference lists, other systematic reviews, conference abstracts, and cross-citation in Google Scholar. Two reviewers independently selected studies, extracted data and assessed the risk of bias. The certainty of the evidence was judged using the GRADE recommendations, a Summary of Findings table is presented. This review complies with PRISMA guidelines and was submitted to PROSPERO registration. Findings: 435 results. After selection process, we included 11 reports corresponding to 4 RCTs. The effect of rtfMRI-nf on improving severity of depression clinical scores showed tendency to favors intervention; however the overall effect was not significant. At end of treatment, SMD(standardized mean difference): -0.32 (95%CI -0.73 to 0.10). At follow-up, SMD: -0.33 (95%CI -0.91, 1.25). All the studies demonstrated changes in BOLD fMRI activation after training; however, only one study demonstrated regulation success during a transfer run. Wholebrain analyses suggests that rt-fMRI nf alters activity patterns not only in a single brain region, but brain networks. More studies are needed to provide an estimated effect on quality of life, acceptability, adverse effects, cognitive tasks, and physiology measures. Conclusions: The current evidence of RCTs about the impact of rt-fMRI-nf training for decision-making outcomes in patients with clinical depression is still insufficient
dc.description.version2022-12-12
dc.fechaingreso.objetodigital2021-12-07
dc.format.extent34 páginas sin numerar
dc.fuente.origenAutoarchivo
dc.identifier.doi10.7764/tesisUC/MED/63034
dc.identifier.urihttps://doi.org/10.7764/tesisUC/MED/63034
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/63034
dc.information.autorucEscuela de Medicina ; Sitaram, Ranganatha ; 0000-0002-8577-8035 ; 1020541
dc.information.autorucEscuela de Medicina ; González Méndez, Pamela Patricia ; S/I ; 1072923
dc.language.isoen
dc.nota.accesoContenido completo
dc.rightsacceso abierto
dc.subject.ddc616.89
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherEnfermedades mentales - Tratamientoes_ES
dc.subject.otherEnfermedades del sistema nervioso - Rehabilitaciónes_ES
dc.subject.otherEnfermedades del sistema nervioso - Terapiaes_ES
dc.subject.otherTrastorno depresivoes_ES
dc.titleReal-time fMRI neurofeedback training as a neurorehabilitation approach on depressive disorders : a systematic review of randomized control trialses_ES
dc.typetesis de maestría
sipa.codpersvinculados1020541
sipa.codpersvinculados1072923
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