Enteral Feeding and Necrotizing Enterocolitis: Does Time of First Feeds and Rate of Advancement Matter?

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dc.catalogadorjwg
dc.contributor.authorMasoli, Daniela
dc.contributor.authorDomínguez De Landa, María Angélica
dc.contributor.authorTapia, Jose L.
dc.contributor.authorUauy, Ricardo
dc.contributor.authorFabres, Jorge
dc.contributor.authorNEOCOSUR Collaborative Network
dc.date.accessioned2024-01-26T12:54:28Z
dc.date.available2024-01-26T12:54:28Z
dc.date.issued2021
dc.description.abstractThe aim of the study was to determine if time to initial enteral feeding (EF) and rate of advancement are associated with necrotizing enterocolitis (NEC) or death. Methods: Secondary analysis of prospectively collected data of very-low-birth-weight infants (VLBWI: 400--1500 g) born in 26 NEOCOSUR centers between 2000 and 2014. Results: Among 12,387 VLBWI, 83.7% survived without NEC, 6.6% developed NEC and survived, and 9.6% had NEC and died or died without NEC (NEC/death). After risk adjustment, time to initial EF (median = 2 days) was not associated with NEC; however, delaying it was protective for NEC/death (odds ratio [OR] = 0.96; 95% confidence interval [CI] 0.93--0.99). A slower feeding advancement rate (FAR) was protective for NEC (OR = 0.97; 95% CI = 0.94-0.98) and for NEC/death (OR = 0.98; 95% CI = 0.96-0.99). Conclusions: In VLBWI, there was no association between an early initial EF and NEC, although delaying it was associated with less NEC/death. A slower FAR was associated with lower risk of both outcomes.
dc.description.funderNEOCOSUR Neonatal Network
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/MPG.0000000000003069
dc.identifier.eissn1536-4801
dc.identifier.issn0277-2116
dc.identifier.pubmedidMEDLINE:33587409
dc.identifier.urihttps://doi.org/10.1097/MPG.0000000000003069
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80967
dc.identifier.wosidWOS:000662032000029
dc.information.autorucEscuela de Medicina; Dominguez De Landa Maria Angelica; 0000-0001-7477-7574; 131798
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final768
dc.pagina.inicio763
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaJOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEnteral Feeding and Necrotizing Enterocolitis: Does Time of First Feeds and Rate of Advancement Matter?
dc.typeartículo
dc.volumen72
sipa.codpersvinculados131798
sipa.trazabilidadORCID;2024-01-15
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