Therapeutic monitoring of antibiotics. New methodologies: biosensors

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dc.contributor.authorSoto, Dagoberto
dc.contributor.authorSilva, Camila
dc.contributor.authorAndresen, Max, V
dc.contributor.authorSoto, Natalia
dc.contributor.authorWong, Kwok Yin
dc.contributor.authorAndresen, Max
dc.date.accessioned2024-01-10T13:43:54Z
dc.date.available2024-01-10T13:43:54Z
dc.date.issued2015
dc.description.abstractThe pharmacokinetics of antibiotics, especially in severely ill patients, may be profoundly altered due to multiple pathophysiological changes. Recent studies have shown that empiric dosing recommendations for ICU patients are inadequate to effectively treat a broad range of susceptible organisms and need to be reconsidered. Therapeutic drug monitoring (TDM) is an important mean for optimizing drug utilization and doses for the purpose of improving the clinical effectiveness. However, it is very challenging to quantify plasma antibiotic concentrations in clinical situations as a routine practice, because of the high costs and complexities associated with advanced instrumental techniques. Currently there are not routine and low cost methods to determine the presence and concentration of beta-lactam antibiotics in plasma patients in a clinical setup. Indeed, such analytical methods are based on chromatographic techniques mainly used in research. Here we describe and comment different techniques, focusing on our preliminary experience using biosensors.
dc.fechaingreso.objetodigital2024-05-29
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0034-98872015000800013
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.pubmedidMEDLINE:26436935
dc.identifier.urihttps://doi.org/10.4067/S0034-98872015000800013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78784
dc.identifier.wosidWOS:000365247400013
dc.information.autorucMedicina;Andresen M;S/I;193472
dc.information.autorucMedicina;Andresen M;S/I;54274
dc.information.autorucMedicina;Soto D;S/I;1008458
dc.information.autorucMedicina;Soto N ;S/I;1011877
dc.issue.numero8
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final1057
dc.pagina.inicio1050
dc.publisherSOC MEDICA SANTIAGO
dc.revistaREVISTA MEDICA DE CHILE
dc.rightsacceso abierto
dc.subjectAnti-bacterial agents
dc.subjectBeta-Lactamase inhibitors
dc.subjectDrug monitoring
dc.subjectFluorescein
dc.subjectPharmacokinetics
dc.subjectCRITICALLY-ILL PATIENTS
dc.subjectBETA-LACTAM ANTIBIOTICS
dc.subjectMILK
dc.subjectVANCOMYCIN
dc.subjectPHARMACOKINETICS
dc.subjectMEROPENEM
dc.subjectRESIDUES
dc.subjectBINDING
dc.subjectSEPSIS
dc.subjectSYSTEM
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleTherapeutic monitoring of antibiotics. New methodologies: biosensors
dc.typeartículo
dc.volumen143
sipa.codpersvinculados193472
sipa.codpersvinculados54274
sipa.codpersvinculados1008458
sipa.codpersvinculados1011877
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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