In-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy

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dc.contributor.authorRamirez, William A.
dc.contributor.authorGizzi, Alessio
dc.contributor.authorSack, Kevin L.
dc.contributor.authorGuccione, Julius M.
dc.contributor.authorHurtado, Daniel E.
dc.date.accessioned2025-01-23T19:49:20Z
dc.date.available2025-01-23T19:49:20Z
dc.date.issued2020
dc.description.abstractBiomaterial injection is a novel therapy to treat ischemic heart failure (HF) that has shown to reduce remodeling and restore cardiac function in recent preclinical studies. While the effect of biomaterial injection in reducing mechanical wall stress has been recently demonstrated, the influence of biomaterials on the electrical behavior of treated hearts has not been elucidated. In this work, we developed computational models of swine hearts to study the electrophysiological vulnerability associated with biomaterial injection therapy. The propagation of action potentials on realistic biventricular geometries was simulated by numerically solving the monodomain electrophysiology equations on anatomically-detailed models of normal, HF untreated, and HF treated hearts. Heart geometries were constructed from high-resolution magnetic resonance images (MRI) where the healthy, peri-infarcted, infarcted and gel regions were identified, and the orientation of cardiac fibers was informed from diffusion-tensor MRI. Regional restitution properties in each case were evaluated by constructing a probability density function of the action potential duration (APD) at different cycle lengths. A comparative analysis of the ventricular fibrillation (VF) dynamics for every heart was carried out by measuring the number of filaments formed after wave braking. Our results suggest that biomaterial injection therapy does not affect the regional dispersion of repolarization when comparing untreated and treated failing hearts. Further, we found that the treated failing heart is more prone to sustain VF than the normal heart, and is at least as susceptible to sustained VF as the untreated failing heart. Moreover, we show that the main features of VF dynamics in a treated failing heart are not affected by the level of electrical conductivity of the biogel injectates. This work represents a novel proof-of-concept study demonstrating the feasibility of computer simulations of the heart in understanding the arrhythmic behavior in novel therapies for HF.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41598-020-69900-4
dc.identifier.issn2045-2322
dc.identifier.urihttps://doi.org/10.1038/s41598-020-69900-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100496
dc.identifier.wosidWOS:000556413400038
dc.issue.numero1
dc.language.isoen
dc.revistaScientific reports
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIn-silico study of the cardiac arrhythmogenic potential of biomaterial injection therapy
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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