Markedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure

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dc.contributor.authorPaz Ocaranza, Maria
dc.contributor.authorGabrielli, Luigi
dc.contributor.authorMora, Italo
dc.contributor.authorGarcia, Lorena
dc.contributor.authorMcNab, Paul
dc.contributor.authorGodoy, Ivan
dc.contributor.authorBraun, Sandra
dc.contributor.authorCordova, Samuel
dc.contributor.authorCastro, Pablo
dc.contributor.authorNovoa, Ulises
dc.contributor.authorChiong, Mario
dc.contributor.authorLavandero, Sergio
dc.contributor.authorJalil, Jorge E.
dc.date.accessioned2024-01-10T13:50:16Z
dc.date.available2024-01-10T13:50:16Z
dc.date.issued2011
dc.description.abstractBackground The small guanosine triphosphatase Rho and its target Rho-kinase have significant roles in experimental remodeling and ventricular dysfunction, but no data are available on Rho-kinase activation in patients with heart failure (HF). We hypothesized that, in patients with chronic HF, Rho-kinase in circulating leukocytes is activated and related to left ventricular (LV) remodeling and dysfunction.
dc.description.abstractMethods Accordingly, Rho-kinase activity, assessed by the levels of phosphorylated to total myosin light chain phosphatase 1 (MYPT1-P/T) in circulating leukocytes, and echocardiographic LV function data were compared between patients with HF New York Heart Association functional class II or III due to systolic dysfunction (n = 17), healthy controls (n = 17), and hypertensive patients without HF (n = 17).
dc.description.abstractResults In the control subjects, mean MYPT1-P/T ratio was 1.2 +/- 0.2 (it was similar in the hypertensive patients without HF), whereas in patients with HF, it was significantly increased by > 100-fold (P < .001). Both MYPT1-P/T and log MYPT1-P/T ratios were inversely correlated with ejection fraction (r = -0.54, P < .03 and r = -0.86, P < .001, respectively). Furthermore, in patients with HF with LV end-diastolic diameter < 60 mm, MYPT1-P/T ratio was 35.8 +/- 18.1, whereas it was significantly higher in patients with LV diameter >= 60 mm (P < .05).
dc.description.abstractConclusions Rho-Kinase activity is markedly increased in patients with stable chronic HF under optimal medical treatment, and it is associated with pathologic LV remodeling and systolic dysfunction. Mechanisms of Rho-kinase activation in patients with HF, its role in the progression of the disease, and the direct effect of Rho-kinase inhibition need further investigation. (Am Heart J 2011;161:931-7.)
dc.fechaingreso.objetodigital2024-03-19
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ahj.2011.01.024
dc.identifier.issn0002-8703
dc.identifier.pubmedidMEDLINE:21570525
dc.identifier.urihttps://doi.org/10.1016/j.ahj.2011.01.024
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79517
dc.identifier.wosidWOS:000290559300025
dc.information.autorucMedicina; Jalil J;S/I;99946
dc.information.autorucMedicina;Braun S ;S/I;102911
dc.information.autorucMedicina;Castro P ;S/I;100212
dc.information.autorucMedicina;Cordova S ;S/I;96819
dc.information.autorucMedicina;Gabrielli L ;S/I;11086
dc.information.autorucMedicina;Godoy I;S/I;70048
dc.information.autorucCiencias Biológicas;Novoa U ;S/I;1000353
dc.information.autorucMedicina;Ocaranza M;S/I;1001254
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final937
dc.pagina.inicio931
dc.publisherMOSBY-ELSEVIER
dc.revistaAMERICAN HEART JOURNAL
dc.rightsacceso restringido
dc.subjectPULMONARY ARTERIAL-HYPERTENSION
dc.subjectLONG-TERM INHIBITION
dc.subjectECHOCARDIOGRAPHIC-ASSESSMENT
dc.subjectCARDIOVASCULAR MEDICINE
dc.subjectCARDIAC-HYPERTROPHY
dc.subjectALDOSTERONE ESCAPE
dc.subjectAMERICAN-SOCIETY
dc.subjectDISEASE
dc.subjectRATS
dc.subjectLYMPHOCYTE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMarkedly increased Rho-kinase activity in circulating leukocytes in patients with chronic heart failure
dc.typeartículo
dc.volumen161
sipa.codpersvinculados99946
sipa.codpersvinculados102911
sipa.codpersvinculados100212
sipa.codpersvinculados96819
sipa.codpersvinculados11086
sipa.codpersvinculados70048
sipa.codpersvinculados1000353
sipa.codpersvinculados1001254
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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