beta 4 Integrin Marks Interstitial Myogenic Progenitor Cells in Adult Murine Skeletal Muscle

Simple item page
dc.contributor.authorLiadaki, Kalliopi
dc.contributor.authorCasar, Juan Carlos
dc.contributor.authorWessen, McKenzie
dc.contributor.authorLuth, Eric S.
dc.contributor.authorJun, Susan
dc.contributor.authorGussoni, Emanuela
dc.contributor.authorKunkel, Louis M.
dc.date.accessioned2024-01-10T13:11:27Z
dc.date.available2024-01-10T13:11:27Z
dc.date.issued2012
dc.description.abstractSkeletal muscle growth and its regeneration following injury rely on myogenic progenitor cells, a heterogeneous population that includes the satellite cells and other interstitial progenitors. The present study demonstrates that surface expression of beta 4 integrin marks a population of vessel-associated interstitial muscle progenitor cells. Muscle beta 4 integrin-positive cells do not express myogenic markers upon isolation. However, they are capable of undergoing myogenic specification in vitro and in vivo: beta 4 integrin cells differentiate into multinucleated myotubes in culture dishes and contribute to muscle regeneration upon delivery into diseased mice. Subfractionation of beta 4 integrin-expressing cells based on CD31 expression does not further enrich for myogenic precursors. These findings support the expression of beta 4 integrin in interstitial, vessel-associated cells with myogenic activity within adult skeletal muscle. (J Histochem Cytochem 60:31-44, 2012)
dc.description.funderNIH
dc.description.funderIDDRC
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
dc.description.funderEUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
dc.description.funderNATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
dc.fechaingreso.objetodigital2024-05-16
dc.format.extent14 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1369/0022155411428991
dc.identifier.issn0022-1554
dc.identifier.pubmedidMEDLINE:22205679
dc.identifier.urihttps://doi.org/10.1369/0022155411428991
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78046
dc.identifier.wosidWOS:000298603800003
dc.information.autorucMedicina;Casar J;S/I;1322
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final44
dc.pagina.inicio31
dc.publisherSAGE PUBLICATIONS LTD
dc.revistaJOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
dc.rightsacceso restringido
dc.subjectbeta 4 integrin
dc.subjectskeletal muscle
dc.subjectprogenitor cells
dc.subjectSIDE-POPULATION CELLS
dc.subjectDUCHENNE MUSCULAR-DYSTROPHY
dc.subjectSTEM-CELLS
dc.subjectSATELLITE CELLS
dc.subjectSELF-RENEWAL
dc.subjectALPHA-6-BETA-4 INTEGRIN
dc.subjectCYTOPLASMIC DOMAINS
dc.subjectGENETIC ANALYSES
dc.subjectCARCINOMA-CELLS
dc.subjectDORSAL AORTA
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlebeta 4 Integrin Marks Interstitial Myogenic Progenitor Cells in Adult Murine Skeletal Muscle
dc.typeartículo
dc.volumen60
sipa.codpersvinculados1322
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
2024-05-16. beta 4 Integrin Marks Interstitial Myogenic Progenitor Cells in Adult Murine Skeletal Muscle.pdf
Size:
2.64 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas