Physical Fitness as a Protective Factor for Cognitive Impairment in a Prospective Population-Based Study in Germany

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dc.contributor.authorSattler, Christine
dc.contributor.authorErickson, Kirk I.
dc.contributor.authorToro, Pablo
dc.contributor.authorSchroeder, Johannes
dc.date.accessioned2024-01-10T13:52:07Z
dc.date.available2024-01-10T13:52:07Z
dc.date.issued2011
dc.description.abstractTo evaluate the predictive effects of subjective measures of physical activity (PA) and objective measures of physical fitness (PF) on dementia risk, participants of the prospective population-based ILSE-study (*1930-1932; 12-year follow-up) were examined at three examination waves (t1 : 1993/94; t2 : 1997/98; t3 : 2005/07). 381 subjects of the original cohort (n = 500) were re-examined at t3. 29% of the subjects who were cognitively healthy at baseline received the diagnosis of mild cognitive impairment (MCI) and 7% of Alzheimer's disease (AD). Subjects were screened for physical and mental health using medical interviews, physical, and neuropsychological examinations. Participants completed a questionnaire on their current and past PA at t1. Subjects were classified as physically active if they reported a regular sport activity for at least 2 hours per week in the past year. Muscular strength (handgrip) and motor coordination (balance) served as objective indicators of PF. Subjects who passed the balance-test at t1 had a reduced risk of developing MCI/AD at t3 (OR = 0.35, 95%CI 0.19-0.66, p < 0.01) and performed significantly better on various neuropsychological measures. Muscular strength or subjective reports of PA did not predict MCI/AD development. Our results confirm the hypothesis that PF acts as a protective factor for the development of cognitive disorders. In our study context, motor coordination served as a better predictor than muscular strength or self-rated PA. Since subjects with cognitive disorders due to cerebral and/or systemic disorders were excluded from the analyses, our findings suggest that the effect of skill-related PF extends beyond the reduction of cardiovascular risk factors.
dc.description.funderState of Baden-Wurttemberg
dc.description.funderFederal Ministry for Family, Senior Citizen, Women, and Youth, Germany
dc.description.funder"Marsilius Kolleg", center of advanced studies, University of Heidelberg, Germany
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent10 páginas
dc.fuente.origenWOS
dc.identifier.doi10.3233/JAD-2011-110548
dc.identifier.eissn1875-8908
dc.identifier.issn1387-2877
dc.identifier.pubmedidMEDLINE:21694450
dc.identifier.urihttps://doi.org/10.3233/JAD-2011-110548
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79645
dc.identifier.wosidWOS:000295843000009
dc.information.autorucMedicina;Pablo Toro;S/I;1597
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final718
dc.pagina.inicio709
dc.publisherIOS PRESS
dc.revistaJOURNAL OF ALZHEIMERS DISEASE
dc.rightsacceso restringido
dc.subjectAging
dc.subjectAlzheimer's disease
dc.subjectcognition
dc.subjectcohort studies
dc.subjectphysical activity
dc.subjectprevention
dc.subjectNEUROLOGICAL SOFT SIGNS
dc.subjectALZHEIMERS-DISEASE
dc.subjectOLDER-ADULTS
dc.subjectRISK-FACTORS
dc.subjectSOCIOECONOMIC-STATUS
dc.subjectLEISURE ACTIVITIES
dc.subjectVASCULAR DEMENTIA
dc.subjectEXERCISE
dc.subjectMIDLIFE
dc.subjectHEALTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePhysical Fitness as a Protective Factor for Cognitive Impairment in a Prospective Population-Based Study in Germany
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1597
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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