Combined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour
dc.contributor.author | Alvarez Lobos, M. | |
dc.contributor.author | Arostegui, J. I. | |
dc.contributor.author | Sans, M. | |
dc.contributor.author | Tassies, D. | |
dc.contributor.author | Piu, J. | |
dc.contributor.author | Reverter, J. C. | |
dc.contributor.author | Pique, J. . M. | |
dc.contributor.author | Yague, J. | |
dc.contributor.author | Panes, J. | |
dc.date.accessioned | 2024-01-10T12:38:06Z | |
dc.date.available | 2024-01-10T12:38:06Z | |
dc.date.issued | 2007 | |
dc.description.abstract | Background NOD2/CARD15 gene variants have not been universally associated with stricturing behaviour in Crohn's disease. Other behaviour modifying genes could explain these results. | |
dc.description.abstract | Aim To study the combined influence of NOD2/CARD15 variants and 4G/4G genotype of type-1 plasminogen activator inhibitor (PAI-1) gene on Crohn's disease behaviour. | |
dc.description.abstract | Methods One hundred and seventy Crohn's disease patients were studied prospectively, with a mean follow-up of 7 +/- 6 years. Disease behaviour was registered by using two criteria: the Vienna classification and a non-hierarchical classification based on the behavioural Vienna categories. | |
dc.description.abstract | Results In the multivariate analysis for stricturing behaviour according to the Vienna categories, only absence of colonic disease (OR, 4.0; 95% CI: 1.49-11.1; P = 0.006) was an independent predictive factor. However, in the multivariate analysis for stricturing disease applying a non-hierarchical criteria, ileal disease (OR, 4.19; 95% CI: 1.30-13.5; P = 0.01), and carrying both NOD2/CARD15 variants and the 4G/4G PAI-1 genotype (OR, 5.02; 95% CI: 1.44-17.48; P = 0.01) were independent predictive factors. In the multivariate analysis for penetrating behaviour, the 4G/4G PAI-1 (OR, 3.10; 95% CI: 1.54-6.23; P = 0.001) and male sex (OR, 2.44; 95% CI: 1.30-4.60; P = 0.005) were independent predictive factors irrespective of criteria applied. | |
dc.description.abstract | Conclusions Combined PAI-1 and NOD2/CARD15 genotyping predict complicated Crohn's disease. Patients with these variants could benefit from early interventions. | |
dc.fechaingreso.objetodigital | 2024-05-07 | |
dc.format.extent | 12 páginas | |
dc.fuente.origen | WOS | |
dc.identifier.doi | 10.1111/j.1365-2036.2006.03208.x | |
dc.identifier.eissn | 1365-2036 | |
dc.identifier.issn | 0269-2813 | |
dc.identifier.pubmedid | MEDLINE:17269998 | |
dc.identifier.uri | https://doi.org/10.1111/j.1365-2036.2006.03208.x | |
dc.identifier.uri | https://repositorio.uc.cl/handle/11534/76984 | |
dc.identifier.wosid | WOS:000243866400009 | |
dc.information.autoruc | Medicina;Álvarez-Lobos M;S/I;6131 | |
dc.issue.numero | 4 | |
dc.language.iso | en | |
dc.nota.acceso | contenido parcial | |
dc.pagina.final | 440 | |
dc.pagina.inicio | 429 | |
dc.publisher | WILEY | |
dc.revista | ALIMENTARY PHARMACOLOGY & THERAPEUTICS | |
dc.rights | acceso restringido | |
dc.subject | INFLAMMATORY-BOWEL-DISEASE | |
dc.subject | PAI-1 PROMOTER POLYMORPHISM | |
dc.subject | INSERTION MUTATION | |
dc.subject | 4G/5G POLYMORPHISM | |
dc.subject | NOD2 GENE | |
dc.subject | CLASSIFICATION | |
dc.subject | VARIANTS | |
dc.subject | INJURY | |
dc.subject | ASSOCIATION | |
dc.subject | SUSCEPTIBILITY | |
dc.subject.ods | 03 Good Health and Well-being | |
dc.subject.odspa | 03 Salud y bienestar | |
dc.title | Combined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour | |
dc.type | artículo | |
dc.volumen | 25 | |
sipa.codpersvinculados | 6131 | |
sipa.index | WOS | |
sipa.index | Scopus | |
sipa.trazabilidad | Carga SIPA;09-01-2024 |
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