Combined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour

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dc.contributor.authorAlvarez Lobos, M.
dc.contributor.authorArostegui, J. I.
dc.contributor.authorSans, M.
dc.contributor.authorTassies, D.
dc.contributor.authorPiu, J.
dc.contributor.authorReverter, J. C.
dc.contributor.authorPique, J. . M.
dc.contributor.authorYague, J.
dc.contributor.authorPanes, J.
dc.date.accessioned2024-01-10T12:38:06Z
dc.date.available2024-01-10T12:38:06Z
dc.date.issued2007
dc.description.abstractBackground NOD2/CARD15 gene variants have not been universally associated with stricturing behaviour in Crohn's disease. Other behaviour modifying genes could explain these results.
dc.description.abstractAim To study the combined influence of NOD2/CARD15 variants and 4G/4G genotype of type-1 plasminogen activator inhibitor (PAI-1) gene on Crohn's disease behaviour.
dc.description.abstractMethods One hundred and seventy Crohn's disease patients were studied prospectively, with a mean follow-up of 7 +/- 6 years. Disease behaviour was registered by using two criteria: the Vienna classification and a non-hierarchical classification based on the behavioural Vienna categories.
dc.description.abstractResults In the multivariate analysis for stricturing behaviour according to the Vienna categories, only absence of colonic disease (OR, 4.0; 95% CI: 1.49-11.1; P = 0.006) was an independent predictive factor. However, in the multivariate analysis for stricturing disease applying a non-hierarchical criteria, ileal disease (OR, 4.19; 95% CI: 1.30-13.5; P = 0.01), and carrying both NOD2/CARD15 variants and the 4G/4G PAI-1 genotype (OR, 5.02; 95% CI: 1.44-17.48; P = 0.01) were independent predictive factors. In the multivariate analysis for penetrating behaviour, the 4G/4G PAI-1 (OR, 3.10; 95% CI: 1.54-6.23; P = 0.001) and male sex (OR, 2.44; 95% CI: 1.30-4.60; P = 0.005) were independent predictive factors irrespective of criteria applied.
dc.description.abstractConclusions Combined PAI-1 and NOD2/CARD15 genotyping predict complicated Crohn's disease. Patients with these variants could benefit from early interventions.
dc.fechaingreso.objetodigital2024-05-07
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1111/j.1365-2036.2006.03208.x
dc.identifier.eissn1365-2036
dc.identifier.issn0269-2813
dc.identifier.pubmedidMEDLINE:17269998
dc.identifier.urihttps://doi.org/10.1111/j.1365-2036.2006.03208.x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76984
dc.identifier.wosidWOS:000243866400009
dc.information.autorucMedicina;Álvarez-Lobos M;S/I;6131
dc.issue.numero4
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final440
dc.pagina.inicio429
dc.publisherWILEY
dc.revistaALIMENTARY PHARMACOLOGY & THERAPEUTICS
dc.rightsacceso restringido
dc.subjectINFLAMMATORY-BOWEL-DISEASE
dc.subjectPAI-1 PROMOTER POLYMORPHISM
dc.subjectINSERTION MUTATION
dc.subject4G/5G POLYMORPHISM
dc.subjectNOD2 GENE
dc.subjectCLASSIFICATION
dc.subjectVARIANTS
dc.subjectINJURY
dc.subjectASSOCIATION
dc.subjectSUSCEPTIBILITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCombined type-1 plasminogen activator inhibitor and NOD2/CARD15 genotyping predicts complicated Crohn's disease behaviour
dc.typeartículo
dc.volumen25
sipa.codpersvinculados6131
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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