Disparities in steatosis prevalence in the United States by Race or Ethnicity according to the 2023 criteria

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dc.article.number219
dc.catalogadorvdr
dc.contributor.authorDíaz, Luis Antonio
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorFuentes López, Eduardo
dc.contributor.authorIdalsoaga Ferrer, Francisco Javier
dc.contributor.authorAyares Campos, Gustavo Ignacio
dc.contributor.authorDesaleng, Hailemichael
dc.contributor.authorDanpanichkul, Pojsakorn
dc.contributor.authorCotter, Thomas G.
dc.contributor.authorDunn, Winston
dc.contributor.authorBarrera, Francisco
dc.contributor.authorWijarnpreecha, Karn
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorAlkhouri, Naim
dc.contributor.authorSingal, Ashwani K.
dc.contributor.authorWong, Robert J.
dc.contributor.authorYounossi, Zobair M.
dc.contributor.authorRinella, Mary E.
dc.contributor.authorKamath, Patrick S.
dc.contributor.authorBataller, Ramon
dc.contributor.authorLoomba, Rohit
dc.contributor.authorArrese Jiménez, Marco
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2024-11-22T16:48:28Z
dc.date.available2024-11-22T16:48:28Z
dc.date.issued2024
dc.description.abstract© The Author(s) 2024.Introduction: The 2023 nomenclature defined criteria for steatotic liver disease (SLD), including metabolic dysfunction-associated SLD (MASLD), alcohol-associated liver disease (ALD), and the overlapping MASLD/ALD (MetALD). We aimed to assess racial and ethnic disparities in the SLD prevalence among United States (US) adults based on this new nomenclature. Methods: We undertook a cross-sectional study employing the 2017–2018 National Health and Nutrition Examination Survey (NHANES) database. We identified SLD according to a controlled attenuation parameter ≥288 dB/m, liver stiffness ≥7.2 kPa, or elevated aminotransferase levels. Alcohol use thresholds were established according to the updated SLD definition. We estimated prevalences using the complex design of the NHANES survey. Multivariable logistic regressions with complex design weights were employed. Results: A total of 5532 individuals are included. The mean age is 45.4 years, and 50.9% are women. The adjusted estimated prevalence of MASLD is 42.4% (95% CI: 41.1–43.8%), MetALD 1.7% (95% CI: 1.3–2.0%), and ALD 0.6% (95% CI: 0.3–0.8%). Hispanics exhibit a higher prevalence of SLD, but there are no significant differences in advanced fibrosis prevalence due to SLD among racial/ethnic groups. In MASLD, men, individuals aged 40–64 and ≥65 years, Hispanics, those with health insurance, higher BMI, diabetes, hypertension, hypertriglyceridemia, and low high-density lipoprotein (HDL) cholesterol or use of lipid-lowering agents are independently associated with a higher risk, while Blacks have the lowest risk. In MetALD, men and higher BMI are independently associated with a higher risk of MetALD in adjusted multivariable analysis. In ALD, the adjusted multivariable analysis shows that only health insurance is independently associated with a lower ALD risk. Conclusions: MASLD prevalence is high in the US, especially in men, older individuals, and Hispanics. MetALD and ALD prevalence was substantial but could be underestimated.
dc.description.funderFONDECYT; Folio de beca: 1241450
dc.fechaingreso.objetodigital2024-11-22
dc.format.extent11 páginas
dc.fuente.origenSCOPUS
dc.fuente.origenORCID
dc.identifier.doi10.1038/s43856-024-00649-x
dc.identifier.issn2730-664X
dc.identifier.scopusidSCOPUS_ID:85208439971
dc.identifier.urihttps://doi.org/10.1038/s43856-024-00649-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88649
dc.information.autorucEscuela de Medicina; Díaz, Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucDepartamento de Ciencias de la Salud; Fuentes López, Eduardo; 0000-0002-0141-0226; 1013849
dc.information.autorucEscuela de Medicina; Idalsoaga Ferrer, Francisco Javier; S/I; 1017394
dc.information.autorucEscuela de Medicina; Ayares Campos, Gustavo Ignacio; S/I; 1033904
dc.information.autorucEscuela de Medicina; Barrera, Francisco; 0000-0001-5334-1528; 14816
dc.information.autorucEscuela de Medicina; Arrese Jiménez, Marco; 0000-0002-0499-4191; 76095
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero2024
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaCommunications Medicine
dc.rightsacceso abierto
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDisparities in steatosis prevalence in the United States by Race or Ethnicity according to the 2023 criteria
dc.typeartículo
dc.volumen4
sipa.codpersvinculados179253
sipa.codpersvinculados1013849
sipa.codpersvinculados1017394
sipa.codpersvinculados1033904
sipa.codpersvinculados14816
sipa.codpersvinculados76095
sipa.codpersvinculados132745
sipa.trazabilidadSCOPUS;2024-11-17
sipa.trazabilidadORCID;2024-11-18
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