Polymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population

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dc.catalogadorvzp
dc.contributor.authorTapia Castillo, Alejandra
dc.contributor.authorCarvajal, Cristian A.
dc.contributor.authorCampino, Carmen
dc.contributor.authorVecchiola, Andrea
dc.contributor.authorAllende, Fidel
dc.contributor.authorSolari, Sandra
dc.contributor.authorGarcia, Lorena
dc.contributor.authorLavanderos, Sergio
dc.contributor.authorValdivia, Carolina
dc.contributor.authorFuentes, Cristobal
dc.contributor.authorLagos, Carlos F.
dc.contributor.authorMartinez Aguayo, Alejandro
dc.contributor.authorBaudrand, Rene
dc.contributor.authorAglony, Marlene
dc.contributor.authorGarcia, Hernan
dc.contributor.authorFardella, Carlos E.
dc.date.accessioned2024-05-31T13:40:24Z
dc.date.available2024-05-31T13:40:24Z
dc.date.issued2014
dc.description.abstractThe GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G > A) and rs836478 (intron 3, T > C) in the RAC1 gene and perform association studies with clinical and biochemical parameters in a Chilean pediatric cohort.
dc.description.abstractTwo hundred two normotensive (NT) subjects (aged 416 years) were divided into 2 groups: NT subjects with hypertensive parents (NH; n 103) and NT subjects with NT parents (NN; n 99). We measured markers of inflammation (high-sensitivity C-reactive protein, interleukin 6 (IL-6), interleukin 8, and tumor necrosis factor ), endothelial damage (Plasminogen activator inhibitor-1 metalloproteinase-9, and metalloproteinase-2), and oxidative stress (malondialdehyde). Data were expressed as median and interquartile range (IQR).
dc.description.abstractWe found differences in polymorphism rs836478 (intron 3, C > T) in both genotypic ((2) 15.2, 2df; P 0.0005) and allelic (X(2)5.5, 1df; P 0.01) frequencies in NH vs. NN subjects. NH subjects with a TT genotype showed increase MMP9 expression (median 2.3, IQR - 1.63.2; vs. median 1.6, IQR 1.62.3 AU; P 0.01) and lower IL-6 expression (median 8.8, IQR 7.011.8; vs. median 12.1, IQR 8.214.7 pg/ml; P 0.02) compared with subjects with TC/CC genotype. No difference in the allelic frequency distribution was seen in the polymorphism rs10951982 (NH vs. NN: (2)0.2, 1df; P 0.6). For this SNP, NN subjects with GA/AA genotype showed decreased diastolic BP indexes compared with subjects with native GG genotype (median 1.08, IQR 1.01.2; vs. median 0.99, IQR 0.941.1; P 0.02).
dc.description.abstractWe report the frequency of polymorphisms rs836478 and rs10951982 of the RAC1 gene in a Spanish-Amerindian cohort. The polymorphism rs836478 was associated with an increased expression in markers of inflammation and endothelial damage (MMP9 and IL-6) in pediatric subjects with a hypertensive genetic background.
dc.format.extent9 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1093/ajh/hpt277
dc.identifier.eissn1941-7225
dc.identifier.issn0895-7061
dc.identifier.urihttps://doi.org/10.1093/ajh/hpt277
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/86159
dc.identifier.wosidWOS:000331842300004
dc.information.autorucEscuela de Medicina; Baudrand Biggs, Rene Felipe; 0000-0002-8655-4957; 1027
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final307
dc.pagina.inicio299
dc.publisherOXFORD UNIV PRESS
dc.revistaAmerican Journal of Hypertension
dc.rightsacceso restringido
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titlePolymorphisms in the RAC1 Gene Are Associated With Hypertension Risk Factors in a Chilean Pediatric Population
dc.typeartículo
dc.volumen27
sipa.codpersvinculados1273
sipa.codpersvinculados1004550
sipa.codpersvinculados1024
sipa.codpersvinculados99519
sipa.codpersvinculados8586
sipa.codpersvinculados66235
sipa.codpersvinculados1006495
sipa.codpersvinculados7337
sipa.codpersvinculados1003862
sipa.codpersvinculados1871
sipa.codpersvinculados118106
sipa.codpersvinculados123319
sipa.codpersvinculados1012854
sipa.codpersvinculados1013775
sipa.codpersvinculados1012852
sipa.trazabilidadORCID;2024-05-27
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