Heart energy metabolism and its role in the treatment of heart failureMetabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca

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dc.contributor.authorCastro P.
dc.contributor.authorGabrielli L.
dc.contributor.authorVerdejo H.
dc.contributor.authorGreig D.
dc.contributor.authorLlevaneras S.
dc.contributor.authorHernández C.
dc.contributor.authorGodoy I.
dc.contributor.authorJalil J.E.
dc.contributor.authorQuintana J.C.
dc.contributor.authorOrellana P.
dc.contributor.authorMellado R.
dc.contributor.authorConcepción R.
dc.contributor.authorSepúlveda L.
dc.contributor.authorVukasovic J.L.
dc.contributor.authorGarcía L.
dc.contributor.authorPizarro M.
dc.contributor.authorPivet D.
dc.contributor.authorCarrillo C.
dc.contributor.authorTapia F.
dc.contributor.authorNavarro M.
dc.contributor.authorTroncoso R.
dc.contributor.authorChiong M.
dc.contributor.authorLavandero S.
dc.contributor.authorLavandero S.
dc.contributor.authorBaraona F.
dc.date.accessioned2024-01-10T13:10:15Z
dc.date.available2024-01-10T13:10:15Z
dc.date.issued2010
dc.description.abstractIt is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the disease and to alterations in myocardial metabolism induced, in part, by this neurohumoral activation. Alterations in cardiac energy metabolism, especially those related to substrate utilization and insulin resistance, reduce the efficiency of energy production, causing a heart energy reserve deficit. These events play a basic role in heart failure progression. Therefore, modulation of cardiac metabolism has arisen as a promissory therapy in the treatment of heart failure. This review describes myocardial energy metabolism, evaluates the role of impaired energy metabolism in heart failure progression and describes new therapies for heart failure involving metabolic intervention.
dc.fuente.origenScopus
dc.identifier.eissn07176163
dc.identifier.issn00349887 07176163
dc.identifier.pubmedid21140063
dc.identifier.scopusidSCOPUS_ID:78649249583
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77815
dc.information.autorucFacultad de Medicina; Verdejo Pinochet, Hugo Eduardo; S/I; 1001175
dc.language.isoes
dc.nota.accesoSin adjunto
dc.pagina.final1039
dc.pagina.inicio1028
dc.revistaRevista Medica de Chile
dc.rightsregistro bibliográfico
dc.subjectDrug therapy
dc.subjectHeart failure
dc.subjectMetabolism
dc.titleHeart energy metabolism and its role in the treatment of heart failureMetabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca
dc.typeartículo
dc.volumen138
sipa.codpersvinculados1001175
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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