A preliminary study on aflatoxin exposure by urine biomonitoring in Chile

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dc.catalogadordfo
dc.contributor.authorFoerster, Claudia
dc.contributor.authorMonsalve, Liliam
dc.contributor.authorMaldonado, Carlos
dc.contributor.authorCortés Arancibia, Sandra
dc.contributor.authorFerreccio, Catterina
dc.date.accessioned2024-01-22T16:22:20Z
dc.date.available2024-01-22T16:22:20Z
dc.date.issued2022
dc.description.abstractWe assessed the occurrence of aflatoxin M1 (AFM1) in urine in a sample of the MAUCO population-based cohort (n = 120) using an enzyme-linked immune sorbent assay (ELISA) kit specially designed for the analysis of AFM1 in urine. We found AFM1 in the urine of 59% of the participants (> limit of detection), with 12% of the samples being over the limit of quantification. The mean of the quantifiable samples was 0.66 (± 0.35) ng/mg adjusted creatinine, ranging from 0.31 to 1.39 ng/mg creatinine. The mean probable daily intake (PDI) of AFB1 was 0.23 (± 0.37) ng/kg bw according to the upper bound (UB), being significantly higher in women and 0.14 (± 0.23) ng/kg bw in the modified lower bound (mLB) approach, ranging from 0.01 to 1.98 ng/kg bw. The risk of AFB1 was assessed with the margin of exposure (MOE) approach estimated at 2800 in the mean mLB and 1733 in the mean UB. According to the MOE values obtained in this study, aflatoxin B1 exposure must be considered a public health concern and must be taken as a priority for food risk management.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1007/s12550-022-00459-x
dc.identifier.eissn1867-1632
dc.identifier.issn0178-7888
dc.identifier.urihttps://doi.org/10.1007/s12550-022-00459-x
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80885
dc.information.autorucEscuela de Medicina; Cortés Arancibia, Sandra; 0000-0003-3293-1419; 1005970
dc.information.autorucEscuela de Medicina; Ferreccio, Catterina; S/I; 99684
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final191
dc.pagina.inicio185
dc.revistaMycotoxin Research
dc.rightsacceso restringido
dc.subjectAflatoxin M1
dc.subjectOccurrence
dc.subjectBiomonitoring
dc.subjectUrine
dc.subjectExposure assessment
dc.subjectAflatoxin B1
dc.subjectChile
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleA preliminary study on aflatoxin exposure by urine biomonitoring in Chile
dc.typeartículo
dc.volumen37
sipa.codpersvinculados1005970
sipa.codpersvinculados99684
sipa.trazabilidadWOS;2022-07-08
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