The impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort

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dc.contributor.authorPons Estel, G. J.
dc.contributor.authorSaurit, V.
dc.contributor.authorAlarcon, G. S.
dc.contributor.authorHachuel, L.
dc.contributor.authorBoggio, G.
dc.contributor.authorWojdyla, D.
dc.contributor.authorAlfaro Lozano, J. L.
dc.contributor.authorGarcia de la Torre, I.
dc.contributor.authorMassardo, L.
dc.contributor.authorEsteva Spinetti, M. H.
dc.contributor.authorGuibert Toledano, M.
dc.contributor.authorRamirez Gomez, L. A.
dc.contributor.authorLavras Costallat, L. T.
dc.contributor.authorSauza del Pozo, M. J.
dc.contributor.authorSilveira, L. H.
dc.contributor.authorCavalcanti, F.
dc.contributor.authorPons Estel, B. A.
dc.date.accessioned2024-01-10T13:43:50Z
dc.date.available2024-01-10T13:43:50Z
dc.date.issued2012
dc.description.abstractObjective: The objective of this paper is to examine the role of place of residency in the expression and outcomes of systemic lupus erythematosus (SLE) in a multi-ethnic Latin American cohort. Patients and methods: SLE patients (<two years of diagnosis) from 34 centers constitute this cohort. Residency was dichotomized into rural and urban, cut-off: 10,000 inhabitants. Socio-demographic, clinical/laboratory and mortality rates were compared between them using descriptive tests. The influence of place of residency on disease activity at diagnosis and renal disease was examined by multivariable regression analyses. Results: Of 1426 patients, 122 (8.6%) were rural residents. Their median ages (onset, diagnosis) were 23.5 and 25.5 years; 85 (69.7%) patients were Mestizos, 28 (22.9%) Caucasians and 9 (7.4%) were African-Latin Americans. Rural residents were more frequently younger at diagnosis, Mestizo and uninsured; they also had fewer years of education and lower socioeconomic status, exhibited hypertension and renal disease more frequently, and had higher levels of disease activity at diagnosis; they used methotrexate, cyclophosphamide pulses and hemodialysis more frequently than urban patients. Disease activity over time, renal damage, overall damage and the proportion of deceased patients were comparable in rural and urban patients. In multivariable analyses, rural residency was associated with high levels of disease activity at diagnosis (OR 1.65, 95% CI 1.06-2.57) and renal disease occurrence (OR 1.77, 95% CI 1.00-3.11). Conclusions: Rural residency associates with Mestizo ethnicity, lower socioeconomic status and renal disease occurrence. It also plays a role in disease activity at diagnosis and kidney involvement but not on the other end-points examined. Lupus (2012) 21, 1397-1404.
dc.description.funderFederico Wilhelm Agricola Foundation Research
dc.description.funderNational Institute of Arthritis and Musculoskeletal and Skin Diseases
dc.description.funderSTELLAR (Supporting Training Efforts in Lupus for Latin American Rheumatologists) Program
dc.description.funderRheuminations Inc.
dc.description.funderInstitut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS)-Beca de Formacio i Contractacio de Personal Investigador
dc.description.funderNATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES
dc.fechaingreso.objetodigital2024-05-15
dc.format.extent8 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1177/0961203312458465
dc.identifier.issn0961-2033
dc.identifier.pubmedidMEDLINE:22941567
dc.identifier.urihttps://doi.org/10.1177/0961203312458465
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78770
dc.identifier.wosidWOS:000310160700004
dc.information.autorucMedicina;Massardo L;S/I;100068
dc.issue.numero13
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1404
dc.pagina.inicio1397
dc.publisherSAGE PUBLICATIONS LTD
dc.revistaLUPUS
dc.rightsacceso restringido
dc.subjectSTAGE RENAL-DISEASE
dc.subjectREVISED CRITERIA
dc.subjectEPIDEMIOLOGY
dc.subjectRISK
dc.subjectCARE
dc.subjectCLASSIFICATION
dc.subjectPOPULATION
dc.subjectEXPOSURES
dc.subjectMORTALITY
dc.subjectACCESS
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe impact of rural residency on the expression and outcome of systemic lupus erythematosus: data from a multiethnic Latin American cohort
dc.typeartículo
dc.volumen21
sipa.codpersvinculados100068
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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