Luteolin: a favonoid with a multifaceted anticancer potential

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dc.article.number386
dc.catalogadorpva
dc.contributor.authorPrasher, Parteek
dc.contributor.authorSharma, Mousmee
dc.contributor.authorSingh, Sachin K.
dc.contributor.authorGulati, Monica
dc.contributor.authorChellappan, Dinesh K.
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorDe Rubis, Gabriele
dc.contributor.authorGupta, Gaurav
dc.contributor.authorSharifi-Rad, Javad
dc.contributor.authorCho, William C.
dc.contributor.authorDua, Kamal
dc.date.accessioned2023-01-26T14:58:05Z
dc.date.available2023-01-26T14:58:05Z
dc.date.issued2022
dc.date.updated2022-12-11T01:02:11Z
dc.description.abstractTherapeutic effect of phytochemicals has been emphasized in the traditional medicine owing to the presence of bioactive molecules, such as polyphenols. Luteolin is a flavone belonging to the flavonoid class of polyphenolic phytochemicals with healing effect on hypertension, inflammatory disorders, and cancer due to its action as pro-oxidants and antioxidants. The anticancer profile of luteolin is of interest due to the toxic effect of contemporary chemotherapy paradigm, leading to the pressing need for the development and identification of physiologically benevolent anticancer agents and molecules. Luteolin exerts anticancer activity by downregulation of key regulatory pathways associated with oncogenesis, in addition to the induction of oxidative stress, cell cycle arrest, upregulation of apoptotic genes, and inhibition of cell proliferation and angiogenesis in cancer cells. In this review, we discuss about the anticancer profile of luteolin.
dc.fechaingreso.objetodigital2022-12-11
dc.format.extent11 páginas
dc.fuente.origenAutoarchivo
dc.identifier.citationCancer Cell International. 2022 Dec 08;22(1):386
dc.identifier.doi10.1186/s12935-022-02808-3
dc.identifier.urihttps://doi.org/10.1186/s12935-022-02808-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/66432
dc.information.autorucFacultad de química y farmacia ; Zacconi, Flavia C. M. ; 0000-0002-3676-0453 ; 1011127
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaCancer Cell International
dc.rightsacceso abierto
dc.rights.holderThe Author(s)
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.titleLuteolin: a favonoid with a multifaceted anticancer potentiales_ES
dc.typeartículo
dc.volumen22
sipa.codpersvinculados1011127
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