The Human Dermis as a Target of Nanoparticles for Treating Skin Conditions

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dc.article.number10
dc.catalogadorgjm
dc.contributor.authorSalazar Muñoz, Javier Alonso
dc.contributor.authorCarmona, Thais
dc.contributor.authorZacconi, Flavia C. M.
dc.contributor.authorVenegas Yazigi, Diego
dc.contributor.authorCabello Verrugio, Claudio
dc.contributor.authorIl Choi, Won
dc.contributor.authorVilos, Cristian
dc.date.accessioned2023-08-24T20:03:55Z
dc.date.available2023-08-24T20:03:55Z
dc.date.issued2023
dc.description.abstractSkin has a preventive role against any damage raised by harmful microorganisms and physical and chemical assaults from the external environment that could affect the body’s internal organs. Dermis represents the main section of the skin, and its contribution to skin physiology is critical due to its diverse cellularity, vasculature, and release of molecular mediators involved in the extracellular matrix maintenance and modulation of the immune response. Skin structure and complexity limit the transport of substances, promoting the study of different types of nanoparticles that penetrate the skin layers under different mechanisms intended for skin illness treatments and dermo-cosmetic applications. In this work, we present a detailed morphological description of the dermis in terms of its structures and resident cells. Furthermore, we analyze the role of the dermis in regulating skin homeostasis and its alterations in pathophysiological conditions, highlighting its potential as a therapeutic target. Additionally, we describe the use of nanoparticles for skin illness treatments focused on dermis release and promote the use of metal-organic frameworks (MOFs) as an integrative strategy for skin treatments.
dc.description.funderNational Research and Development Agency
dc.description.funderNational Fund for Science & Technology Development
dc.description.funderFONDECYT
dc.description.funderHorizon 2020 Research and Innovation Program
dc.description.funderUniversidad de Talca
dc.fechaingreso.objetodigital2023-08-24
dc.format.extent18 páginas
dc.fuente.origenSIPA
dc.identifier.doi10.3390/pharmaceutics15010010
dc.identifier.eissn1999-4923
dc.identifier.issn1999-4923
dc.identifier.scopusidSCOPUS_ID:85146751093
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics15010010
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/74487
dc.information.autorucFacultad de Química; Salazar Muñoz, Javier Alonso; 0000-0001-6969-9321; 1059920
dc.information.autorucEscuela de Química; Zacconi, Flavia C. M.; 0000-0002-3676-0453; 1011127
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido completo
dc.revistaPharmaceutics
dc.rightsacceso abierto
dc.subjectDermis
dc.subjectDrug delivery
dc.subjectMetal-organic frameworks (MOFs)
dc.subjectNanoparticles
dc.subjectSkin
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThe Human Dermis as a Target of Nanoparticles for Treating Skin Conditions
dc.typeartículo
dc.volumen15
sipa.codpersvinculados1059920
sipa.codpersvinculados1011127
sipa.indexSCOPUS
sipa.trazabilidadSCOPUS;02-03-2023
sipa.trazabilidadORCID;2023-08-21
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