Genetic and pharmacological modulation of dendritic cell-T cell interactions as a therapeutic strategy for systemic lupus erythematosus.

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dc.catalogadorpau
dc.contributor.authorLlanos, Carolina
dc.contributor.authorCarreno, Leandro J.
dc.contributor.authorGutierrez, Miguel A.
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorJacobelli, Sergio H.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-03-07T18:57:17Z
dc.date.available2024-03-07T18:57:17Z
dc.date.issued2011
dc.description.abstractSystemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by an excessive production of auto-antibodies against double-stranded DNA, nucleosomes, ribonucleoproteins and other nuclear components. Accumulation of self-reactive antibodies leads to immune complex deposition in blood vessels, activation of macrophages and complement, inflammation and subsequent tissue damage in several organs, such as the heart, kidneys, lungs and central nervous system. Although significant progress has been made in the past 30 years of research, no effective specific treatments are currently available. The course of this disease remains unpredictable and patients diagnosed with SLE face long-term treatments with the subsequent economic, social and health burden. From the immunological perspective, SLE is a genetic- and environment-controlled disease that involves almost every constituent of the immune system, including both innate and adaptive immunity. Therefore, several immune cell types and molecules could be susceptible for intervention and modulation to develop more effective and specific treatments. More importantly, such therapies are likely not to induce complete immunosuppression and show reduced side effects on patients. In this article we discuss recent work in the field of SLE pathogenesis with a focus on data that provide clues for therapy design and new treatments.
dc.fuente.origenORCID
dc.identifier.doi10.2174/156652311798192806
dc.identifier.urihttps://doi.org/10.2174/156652311798192806
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/84292
dc.information.autorucEscuela de Medicina; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.language.isoen
dc.nota.accesoContenido parcial
dc.rightsacceso restringido
dc.titleGenetic and pharmacological modulation of dendritic cell-T cell interactions as a therapeutic strategy for systemic lupus erythematosus.
dc.typeartículo
sipa.codpersvinculados90610
sipa.trazabilidadORCID;2024-01-15
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