Upper limits of laser pulse widths required for melanosome and epidermal specific damage

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dc.contributor.authorCarrazana, P.
dc.contributor.authorFriedli Lluch, Carlos
dc.date.accessioned2019-12-28T02:45:13Z
dc.date.available2019-12-28T02:45:13Z
dc.date.issued1988
dc.description.abstractA critical analysis of thermal relaxation times used as an upper limit of laser pulse widths after the absorption of laser radiation by pigmented epidermal lesions has been made. Only the case in which the radiation is absorbed mainly by melanin-containing melanosomes within the tissue is treated. Two of the known criteria currently used to estimate relaxation times are compared, and relaxation times based on an exact solution of the heat conduction equation are found. Numerical results indicate that the relaxation times needed for the temperature to reach its maximum value at a given distance from the melanosome are in the range 0?5.0 ?s when the distance varies in the range 0.5?2.0 ?m for a typical melanosome radius of 0.5 ?m, and for laser pulse widths much shorter than the corresponding non-zero relaxation times. It is shown that, with visible and ultraviolet laser pulses, it is difficult selectively to damage epidermal lesions that have a low density of melanosomes. It is suggested, therefore, that these lesions can be treated with low-fluence infrared radiation from, for example, a CO2 laser. This suggestion agrees with experimental results published by other authors.
dc.format.extent7 páginas
dc.fuente.origenSpringer
dc.identifier.doi10.1007/BF02593821
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/27067
dc.identifier.urihttp://link.springer.com/article/10.1007/BF02593821
dc.issue.numeroNo. 43556
dc.language.isoen
dc.pagina.final266
dc.pagina.inicio259
dc.revistaLasers in Medical Sciencees_ES
dc.rightsacceso restringido
dc.subjectLaser damagees_ES
dc.subjectThermal modellinges_ES
dc.subjectBiological tissuees_ES
dc.subjectRelaxation timees_ES
dc.subjectEpidermal lesiones_ES
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleUpper limits of laser pulse widths required for melanosome and epidermal specific damagees_ES
dc.typeartículo
dc.volumenVol. 3
sipa.codpersvinculados98374
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