Baseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal samples

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dc.contributor.authorFerreccio Readi, Catterina
dc.contributor.authorCorvalán R., Alejandro
dc.contributor.authorMargozzini Maira, Paula
dc.contributor.authorViviani García, Paola
dc.contributor.authorGonzález, Claudia
dc.contributor.authorAguilera, Ximena
dc.contributor.authorGravitt, Patti E
dc.date.accessioned2019-10-16T20:49:43Z
dc.date.available2019-10-16T20:49:43Z
dc.date.issued2008
dc.date.updated2019-10-14T18:32:31Z
dc.description.abstractAbstract Background Chile has broad variations in weather, economics and population from the far desert north (Region 1) to the cold, icy south (Region 12). A home-based self-collected vaginal sampling was nested in the 2003 Chilean population-based health survey in order to explore the possibility of a type-specific geographical variation for human papillomavirus Methods The population was a national probability sample of people 17 years of age and over. Consenting women provided self-collected cervicovaginal swabs in universal collection media (UCM). DNA was extracted and typed to 37 HPV genotypes using PGMY consensus PCR and line blot assay. Weighted prevalence rates and adjusted OR were calculated. Results Of the 1,883 women participating in the health survey, 1,219 (64.7%) provided a cervicovaginal sample and in 1,110 (56.2% of participants and 66.5% of those eligible) the samples were adequate for analysis. Refusal rate was 16.9%. HPV prevalence was 29.2% (15.1% high-risk HPV and 14.1% low-risk HPV). Predominant high-risk types were HPV 16, 52, 51, 56 and 58. Predominant low-risk HPVs were HPV 84, CP6108, 62, 53 and 61. High-risk and low-risk HPV rates were inversely correlated between the regions. High-risk HPV prevalence was highest among the youngest women, whereas low-risk HPV increased slightly with age. Conclusion Self-obtained vaginal sampling is adequate for monitoring HPV in the community, for identifying high-risk areas, and for surveying the long term impact of interventions.
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Public Health. 2008 Feb 28;8(1):78
dc.identifier.doi10.1186/1471-2458-8-78
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26576
dc.issue.numeroNo. 78
dc.language.isoen
dc.pagina.final12
dc.pagina.inicio1
dc.revistaBMC Public Healthes_ES
dc.rightsacceso abierto
dc.rights.holderFerreccio et al; licensee BioMed Central Ltd.
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.otherVirus del Papiloma - Chilees_ES
dc.subject.otherVirus del Papiloma - Estadisticaes_ES
dc.subject.otherEnfermedades infecciosases_ES
dc.titleBaseline assessment of prevalence and geographical distribution of HPV types in Chile using self-collected vaginal sampleses_ES
dc.typeartículo
dc.volumenVol. 8
sipa.codpersvinculados99684
sipa.codpersvinculados63885
sipa.codpersvinculados63265
sipa.codpersvinculados729
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